INPP4A

From Wikipedia, the free encyclopedia

Inositol polyphosphate-4-phosphatase, type I, 107kDa

Identifiers

External IDs

OMIM: 600916 MGI: 1931123 HomoloGene: 2871

Gene ontology
Molecular Function:	• phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity • hydrolase activity
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001566 (mRNA)
NP_001557 (protein)

XM_978104 (mRNA)
XP_983198 (protein)

Location

Chr 2: 98.43 - 98.57 Mb

Chr 1: 37.3 - 37.35 Mb

Pubmed search

[1]

[2]

Inositol polyphosphate-4-phosphatase, type I, 107kDa, also known as INPP4A, is a human gene.^[1]

INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.^[1]

[edit] References

^ ^a ^b Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa.

[edit] Further reading

Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions.". Semin. Cell Dev. Biol. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
Norris FA, Auethavekiat V, Majerus PW (1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.". J. Biol. Chem. 270 (27): 16128–33. PMID 7608176.
Norris FA, Atkins RC, Majerus PW (1997). "Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets.". J. Biol. Chem. 272 (17): 10987–9. PMID 9110986.
Norris FA, Atkins RC, Majerus PW (1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.". J. Biol. Chem. 272 (38): 23859–64. PMID 9295334.
Munday AD, Norris FA, Caldwell KK, et al. (1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3640–5. PMID 10097090.
Joseph RE, Walker J, Norris FA (2000). "Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization.". Cytogenet. Cell Genet. 87 (3-4): 276–7. PMID 10702694.
Shearn CT, Walker J, Norris FA (2001). "Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene.". Biochem. Biophys. Res. Commun. 286 (1): 119–25. doi:10.1006/bbrc.2001.5331. PMID 11485317.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ivetac I, Munday AD, Kisseleva MV, et al. (2005). "The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.". Mol. Biol. Cell 16 (5): 2218–33. doi:10.1091/mbc.E04-09-0799. PMID 15716355.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.