INPP1

From Wikipedia, the free encyclopedia

Inositol polyphosphate-1-phosphatase

Identifiers

INPP1; MGC110984

External IDs

OMIM: 147263 MGI: 104848 HomoloGene: 1655

Gene ontology
Molecular Function:	• magnesium ion binding • inositol or phosphatidylinositol phosphatase activity • inositol-1,4-bisphosphate 1-phosphatase activity • hydrolase activity • lithium ion binding
Biological Process:	• phosphate metabolic process • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002194 (mRNA)
NP_002185 (protein)

NM_008384 (mRNA)
NP_032410 (protein)

Location

Chr 2: 190.92 - 190.94 Mb

Chr 1: 52.73 - 52.76 Mb

Pubmed search

[1]

[2]

Inositol polyphosphate-1-phosphatase, also known as INPP1, is a human gene.^[1]

INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.^[1]

[edit] References

^ ^a ^b Entrez Gene: INPP1 inositol polyphosphate-1-phosphatase.

[edit] Further reading

Majerus PW, Ross TS, Cunningham TW, et al. (1990). "Recent insights in phosphatidylinositol signaling.". Cell 63 (3): 459–65. PMID 2225061.
Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions.". Semin. Cell Dev. Biol. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
York JD, Veile RA, Donis-Keller H, Majerus PW (1993). "Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5833–7. PMID 8390685.
Steen VM, Løvlie R, Osher Y, et al. (1998). "The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness.". Pharmacogenetics 8 (3): 259–68. PMID 9682271.
Løvlie R, Gulbrandsen AK, Molven A, Steen VM (2000). "Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1).". Pharmacogenetics 9 (4): 517–28. PMID 10780272.
Patel S, Yenush L, Rodríguez PL, et al. (2002). "Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy.". J. Mol. Biol. 315 (4): 677–85. doi:10.1006/jmbi.2001.5271. PMID 11812139.
Piccardi MP, Ardau R, Chillotti C, et al. (2002). "Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.". Psychiatr. Genet. 12 (1): 23–7. PMID 11901356.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.