Inositol-tetrakisphosphate 5-kinase

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In enzymology, an inositol-tetrakisphosphate 5-kinase (EC 2.7.1.140) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate $\rightleftharpoons$ ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,3,4,6-tetrakisphosphate, whereas its two products are ADP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase. This enzyme is also called 1D-myo-inositol-tetrakisphosphate 5-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

[edit] References

IUBMB entry for 2.7.1.140
BRENDA references for 2.7.1.140 (Recommended.)
PubMed references for 2.7.1.140
PubMed Central references for 2.7.1.140
Google Scholar references for 2.7.1.140
Shears SB (1989). "The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase". J. Biol. Chem. 264: 19879–86. PMID 2584198.
Stevenson-Paulik J, Odom AR, York JD (2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277: 42711–8. doi:10.1074/jbc.M209112200. PMID 12226109.