Inositol-pentakisphosphate 2-kinase

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In enzymology, an inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate $\rightleftharpoons$ ADP + 1D-myo-inositol hexakisphosphate

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate, whereas its two products are ADP and 1D-myo-inositol hexakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase. Other names in common use include IP5 2-kinase, Gsl1p, Ipk1p, inositol polyphosphate kinase, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, and Ins(1,3,4,5,6)P5 2-kinase.

[edit] References

IUBMB entry for 2.7.1.158
BRENDA references for 2.7.1.158 (Recommended.)
PubMed references for 2.7.1.158
PubMed Central references for 2.7.1.158
Google Scholar references for 2.7.1.158
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Phillippy BQ, Ullah AH and Ehrlich KC (1997). "Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds". J. Biol. Chem. 270: 7782. doi:10.1074/jbc.270.13.7782.
Ongusaha PP, Hughes PJ, Davey J, Michell RH (Pt 3). "Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation". Biochem. J. 335: 671–9. PMID 9794810.
Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR (2004). "Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway". J. Biol. Chem. 279: 51022–32. doi:10.1074/jbc.M409394200. PMID 15459192.
Stevenson-Paulik J, Odom AR, York JD (2002). "Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases". J. Biol. Chem. 277: 42711–8. doi:10.1074/jbc.M209112200. PMID 12226109.