Inositol-3-phosphate synthase

From Wikipedia, the free encyclopedia

In enzymology, an inositol-3-phosphate synthase (EC 5.5.1.4) is an enzyme that catalyzes the chemical reaction

D-glucose 6-phosphate 1D-myo-inositol 3-phosphate

Hence, this enzyme has one substrate, D-glucose 6-phosphate, and one product, 1D-myo-inositol 3-phosphate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 1D-myo-inositol-3-phosphate lyase (isomerizing). Other names in common use include myo-inositol-1-phosphate synthase, D-glucose 6-phosphate cycloaldolase, inositol 1-phosphate synthatase, glucose 6-phosphate cyclase, inositol 1-phosphate synthetase, glucose-6-phosphate inositol monophosphate cycloaldolase, glucocycloaldolase, and 1L-myo-inositol-1-phosphate lyase (isomerizing). This enzyme participates in streptomycin biosynthesis and inositol phosphate metabolism. It employs one cofactor, NAD+.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1GR0, 1JKF, 1JKI, 1LA2, 1P1F, 1P1H, 1P1I, 1P1J, 1P1K, 1RM0, 1VJP, and 1VKO.

[edit] References

• IUBMB entry for 5.5.1.4
• BRENDA references for 5.5.1.4 (Recommended.)
• PubMed references for 5.5.1.4
• PubMed Central references for 5.5.1.4
• Google Scholar references for 5.5.1.4
• Eisenberg F Jr (1967). "D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis". J. Biol. Chem. 242: 1375–82. PMID 4290245. 
• Sherman WR, Stewart MA, Zinbo M (1969). "Mass spectrometric study on the mechanism of D-glucose 6-phosphate-L-myo-inositol 1-phosphate cyclase". J. Biol. Chem. 244: 5703–8. PMID 4310603. 
• Barnett JE, Corina DL (1968). "The mechanism of glucose 6-phosphate-D-myo-inositol 1-phosphate cyclase of rat testis. The involvement of hydrogen atoms". Biochem. J. 108: 125–9. PMID 4297937. 
• Barnett JE, Rasheed A, Corina DL (1973). "Partial reactions of D-glucose 6-phosphate-1L-myoinositiol 1-phosphate cyclase". Biochem. J. 131: 21–30. PMID 4352864. 

[edit] External links

The CAS registry number for this enzyme class is 9032-95-5.

• IUBMB entry for 5.5.1.4

• KEGG entry for 5.5.1.4

• BRENDA entry for 5.5.1.4

• NiceZyme view of 5.5.1.4

• EC2PDB: PDB structures for 5.5.1.4

• PRIAM entry for 5.5.1.4

• PUMA2 entry for 5.5.1.4

• IntEnz: Integrated Enzyme entry for 5.5.1.4

• MetaCyc entry for 5.5.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004512: inositol-3-phosphate synthase

• AMIGO entry for GO code 0004512: inositol-3-phosphate synthase