Inosine nucleosidase

From Wikipedia, the free encyclopedia

In enzymology, an inosine nucleosidase (EC 3.2.2.2) is an enzyme that catalyzes the chemical reaction

inosine + H₂O D-ribose + hypoxanthine

Thus, the two substrates of this enzyme are inosine and H₂O, whereas its two products are D-ribose and hypoxanthine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is inosine ribohydrolase. Other names in common use include inosinase, and inosine-guanosine nucleosidase. This enzyme participates in purine metabolism.

[edit] References

• IUBMB entry for 3.2.2.2
• BRENDA references for 3.2.2.2 (Recommended.)
• PubMed references for 3.2.2.2
• PubMed Central references for 3.2.2.2
• Google Scholar references for 3.2.2.2
• KOCH AL (1956). "Some enzymes of nucleoside metabolism of Escherichia coli". J. Biol. Chem. 223: 535–49. PMID 13376622. 
• Tarr HLA (1955). "Fish muscle riboside hydrolases". Biochem. J. 59: 386–391. 

[edit] External links

The CAS registry number for this enzyme class is 9030-95-9.

• IUBMB entry for 3.2.2.2

• KEGG entry for 3.2.2.2

• BRENDA entry for 3.2.2.2

• NiceZyme view of 3.2.2.2

• EC2PDB: PDB structures for 3.2.2.2

• PRIAM entry for 3.2.2.2

• PUMA2 entry for 3.2.2.2

• IntEnz: Integrated Enzyme entry for 3.2.2.2

• MetaCyc entry for 3.2.2.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047724: inosine nucleosidase

• AMIGO entry for GO code 0047724: inosine nucleosidase