Inorganic diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, an inorganic diphosphatase (EC 3.6.1.1) is an enzyme that catalyzes the chemical reaction

diphosphate + H₂O $\rightleftharpoons$ 2 phosphate

Thus, the two substrates of this enzyme are diphosphate and H₂O, whereas its product is phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is diphosphate phosphohydrolase. This enzyme participates in oxidative phosphorylation. It employs one cofactor, metal.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 56 structures have been solved for this class of enzymes, with PDB accession codes 117E, 1E6A, 1E9G, 1FAJ, 1HUJ, 1HUK, 1I40, 1I6T, 1I74, 1IGP, 1INO, 1IPW, 1JFD, 1K20, 1K23, 1M38, 1MJW, 1MJX, 1MJY, 1MJZ, 1OBW, 1PYP, 1QEZ, 1SXV, 1TWL, 1UDE, 1WCF, 1WGI, 1WGJ, 1WPM, 1WPN, 1WPP, 1YGZ, 1YPP, 2AU6, 2AU7, 2AU8, 2AU9, 2AUU, 2BQX, 2BQY, 2EB0, 2EIP, 2ENX, 2HAW, 2IHP, 2IK0, 2IK1, 2IK2, 2IK4, 2IK6, 2IK7, 2IK9, 2IW4, 2PRD, and 8PRK.

[edit] References

IUBMB entry for 3.6.1.1
BRENDA references for 3.6.1.1 (Recommended.)
PubMed references for 3.6.1.1
PubMed Central references for 3.6.1.1
Google Scholar references for 3.6.1.1
Bailey K and Webb EC (1944). "Purification and properties of yeast pyrophosphatase". Biochem. J. 38: 394–398.
KUNITZ M (1952). "Crystalline inorganic pyrophosphatase isolated from baker's yeast". J. Gen. Physiol. 35: 423–50. doi:10.1085/jgp.35.3.423. PMID 14898026.
Rafter GW (1960). "Pyrophosphate metabolism in liver mitochondria". J. Biol. Chem. 235: 2475–2477.