INHBC

From Wikipedia, the free encyclopedia

Inhibin, beta C

Identifiers

External IDs

OMIM: 601233 MGI: 105932 HomoloGene: 21142

Gene ontology
Molecular Function:	• transforming growth factor beta receptor binding • hormone activity • growth factor activity
Cellular Component:	• extracellular region

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005538 (mRNA)
NP_005529 (protein)

NM_010565 (mRNA)
NP_034695 (protein)

Location

Chr 12: 56.11 - 56.13 Mb

Chr 10: 126.76 - 126.77 Mb

Pubmed search

[1]

[2]

Inhibin, beta C, also known as INHBC, is a human gene.^[1]

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.^[1]

[edit] References

^ ^a ^b Entrez Gene: INHBC inhibin, beta C.

[edit] Further reading

Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction.". Recent Prog. Horm. Res. 56: 417-50. PMID 11237224.
Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase.". Cell 65 (6): 973-82. PMID 1646080.
H tten G, Neidhardt H, Schneider C, Pohl J (1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain.". Biochem. Biophys. Res. Commun. 206 (2): 608-13. PMID 7826378.
Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.". Genomics 32 (3): 358-66. doi:10.1006/geno.1996.0130. PMID 8838799.
Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.". Prostate 34 (1): 34-43. PMID 9428386.
Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.". J. Clin. Endocrinol. Metab. 85 (12): 4851-8. PMID 11134153.
Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.". Mol. Hum. Reprod. 9 (4): 199-203. PMID 12651901.
Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.". Endocrinology 144 (10): 4410-9. doi:10.1210/en.2003-0225. PMID 12960042.
Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein.". J. Reprod. Dev. 52 (4): 487-95. PMID 16627954.