INHBB

From Wikipedia, the free encyclopedia

Inhibin, beta B (activin AB beta polypeptide)

Identifiers

External IDs

OMIM: 147390 MGI: 96571 HomoloGene: 1654

Gene ontology
Molecular Function:	• cytokine activity • hormone activity • growth factor activity • protein homodimerization activity • host cell surface receptor binding
Cellular Component:	• extracellular region
Biological Process:	• ovarian follicle development • defense response • response to external stimulus • cell differentiation • growth • positive regulation of follicle-stimulating hormone secretion • negative regulation of follicle-stimulating hormone secretion • negative regulation of hepatocyte growth factor biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002193 (mRNA)
NP_002184 (protein)

XM_984243 (mRNA)
XP_989337 (protein)

Location

Chr 2: 120.82 - 120.83 Mb

Chr 1: 121.24 - 121.25 Mb

Pubmed search

[1]

[2]

Inhibin, beta B (activin AB beta polypeptide), also known as INHBB, is a human gene.^[1]

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.^[1]

[edit] References

^ ^a ^b Entrez Gene: INHBB inhibin, beta B (activin AB beta polypeptide).

[edit] Further reading

Ying SY (1988). "Inhibins and activins: chemical properties and biological activity.". Proc. Soc. Exp. Biol. Med. 186 (3): 253–64. PMID 3122219.
Munz B, Hübner G, Tretter Y, et al. (1999). "A novel role of activin in inflammation and repair.". J. Endocrinol. 161 (2): 187–93. PMID 10320815.
Welt CK (2002). "The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction.". Curr. Opin. Obstet. Gynecol. 14 (3): 317–23. PMID 12032389.
Shav-Tal Y, Zipori D (2003). "The role of activin a in regulation of hemopoiesis.". Stem Cells 20 (6): 493–500. PMID 12456957.
Lahlou N, Roger M (2005). "Inhibin B in pubertal development and pubertal disorders.". Semin. Reprod. Med. 22 (3): 165–75. doi:10.1055/s-2004-831892. PMID 15319819.
Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase.". Cell 65 (6): 973–82. PMID 1646080.
Schmelzer CH, Burton LE, Tamony CM, et al. (1990). "Purification and characterization of recombinant human activin B.". Biochim. Biophys. Acta 1039 (2): 135–41. PMID 2364091.
Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). "Activin B: precursor sequences, genomic structure and in vitro activities.". Mol. Endocrinol. 3 (9): 1352–8. PMID 2575216.
Feng ZM, Bardin CW, Chen CL (1989). "Characterization and regulation of testicular inhibin beta-subunit mRNA.". Mol. Endocrinol. 3 (6): 939–48. PMID 2739657.
Barton DE, Yang-Feng TL, Mason AJ, et al. (1989). "Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice.". Genomics 5 (1): 91–9. PMID 2767687.
Burger HG, Igarashi M (1988). "Inhibin: definition and nomenclature, including related substances.". Endocrinology 122 (4): 1701–2. PMID 3345731.
Mason AJ, Niall HD, Seeburg PH (1986). "Structure of two human ovarian inhibins.". Biochem. Biophys. Res. Commun. 135 (3): 957–64. PMID 3754442.
Martens JW, de Winter JP, Timmerman MA, et al. (1997). "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells.". Endocrinology 138 (7): 2928–36. PMID 9202237.
Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. PMID 11134153.
Chapman SC, Woodruff TK (2001). "Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).". Mol. Endocrinol. 15 (4): 668–79. PMID 11266516.
Salmenkivi K, Arola J, Voutilainen R, et al. (2001). "Inhibin/activin betaB-subunit expression in pheochromocytomas favors benign diagnosis.". J. Clin. Endocrinol. Metab. 86 (5): 2231–5. PMID 11344232.
Bahathiq AO, Stewart RL, Wells M, et al. (2002). "Production of activins by the human endosalpinx.". J. Clin. Endocrinol. Metab. 87 (11): 5283–9. PMID 12414903.