ING5

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Inhibitor of growth family, member 5
PDB rendering based on 1wen.
Available structures: 1wen, 2jmq
Identifiers
Symbol(s) ING5; FLJ23842; p28ING5
External IDs OMIM: 608525 HomoloGene: 88937
Orthologs
Human Mouse
Entrez 84289 n/a


Refseq XM_941026 (mRNA)
XP_946119 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

Inhibitor of growth family, member 5, also known as ING5, is a human gene.[1]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.[1]

[edit] References

  1. ^ a b Entrez Gene: ING5 inhibitor of growth family, member 5.

[edit] Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853-65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Shiseki M, Nagashima M, Pedeux RM, et al. (2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.". Cancer Res. 63 (10): 2373-8. PMID 12750254. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
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