Talk:Inflammatory breast cancer

From Wikipedia, the free encyclopedia

	This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess.
Stub	This page has been rated as Stub-Class on the quality assessment scale
Mid	This article has been rated as Mid-importance on the importance assessment scale

[edit] this

this needs a merge with KEEPING the info about bug bites / embarassed teens. the word needs to get out, and it will do so much better on the larger and more visited BC page. moving this info there might just save a life.

[edit] Merging with other types of Breast Cancer:

Inflammatory breast cancer should have a separate section because one of the only things that it has in common with other types of breast cancer is that it usually involves the breasts. Inflammatory breast cancer normally presents with very different symptoms than other types of breast cancer in that it usually does not form a lump and is not detectable on a mammogram or ultrasound. Many IBC patients receive clear mammograms shortly before they are diagnosed with IBC. IBC is also much deadlier than the normal types of breast cancer. Statistics are indicating that breast cancer has a 97-98% survival rate, but IBC patients are lucky if 40% of them survive for even 5 years. Their 10-year survival rates are much lower. IBC is the most aggressive of the breast cancers and is much more likely to metastasize (spread). IBC should almost always be treated with chemotherapy first to decrease the size of the breast and increase the chances for clear margins, whereas most types of breast cancer receive surgery first. IBC almost always causes pain whereas other types of breast cancer rarely do in the initial stages. IBC is staged as either III or IV. It is never staged as I or II like most other breast cancers. IBC patients are almost never able to receive a lumpectomy - especially compared to many, if not most, other types of breast cancer. I could go on and on regarding the differences between IBC and other types of breast cancer. It is a disservice to the medical community, breast cancer patients, and the general public to not reinforce the differences and seriousness of Inflammatory breast cancer compared to more common types of breast cancer.

You will agree that IBC is a type of BC. That article happens to be in dire need of a serious cleanup, but I would recommend a merge. As a clinical entity, IBC is treated as breast cancer - surgically, with chemotherapy. I am I favour of reducing the content of this article to a clear concise paragraph in breast cancer. JFW | T@lk 03:43, 14 Sep 2004 (UTC)

I agree with JFW. Even though IBC is treated differently, this is an encyclopedia article not a support group. Considering metastatic breast cancer doesn't have its own page (and that's a much bigger topic), this can be easily combined. Pete Bevin 10 Apr 2005

I am in favour of keeping a separate entry - imho IBC is a distinct lexical entity and that is reason enough for an own entry. It needs a cleanup, thats for sure. The part about teenagers needs fixing as IBC affects almost all age groups. --Richiez 20:38, 13 February 2007 (UTC)

A pathologic complete remission (pCR) predicts improved survival in breast cancer (BC)ASCO abstract describes a 63% rate of complete pathologic response in Her-2+ inflammatory breast cancer following paclitaxel/carboplatin and trastuzumab. ASCO 2006;abstract #10583 Authors: Mehta RS, Schubbert T, Kong K A pathological complete remission (pCR) predicts improved survival in breast cancer (BC). Treatment with AC followed by concurrent TCH improved pCR rates to 87.5% in Her2 positive 8-patient pilot study (SABCS 2004, abs #1110), confirmed by a subsequent phase II study. We hypothesized that response adjusted AC (2-4 cycles), TCH (3-4 cycles) sequence targets topoisomerase II alpha amplified and deleted clone, respectively (SABCS 2005, abs # 5056). We report here the combined analysis of the Her2 positive (fluorescence in situ hybridization + or immunohistochemistry 3+) subset of these studies. Material and Methods: Thirty-one patients with stage IIB-IV BC were accrued. Twenty-eight of 31 patients received AC in a dose dense manner with GM-CSF support. Patients received carboplatin calculated at AUC of 2 and paclitaxel at 80 mg/m2 for 3 weeks followed by 1 week of rest (1 cycle) for a maximum of 4 cycles. Concurrent trastuzumab 4 mg/kg loading dose, then 2 mg/kg/wk was administered for 12-16 weeks. Results: Twenty-nine of 31(94%, CI, 0.79-1) patients showed a clinical complete or partial response (cCR, or cPR). Nineteen of 27 patients (70%, CI, 0.50-0.86) achieved a pCR at surgery; two additional patients had <3 mm residual invasive cancer; and lymph node negativity rate was 73%. Of the 3 additional patients with cCR, 1died (underlying cirrhosis), 1 refused surgery, and 1 awaits surgery. A fourth patient with cPR awaits surgery. Ninety percent of the patients (28/31, CI, 0.74-0.98) are alive, and 77% (24/31, CI, 0.59-0. 90) are progression free at median follow up of 19 months (range 6-35 months). Median ejection fraction by echocardiogram was 60% (range 50-74); no patient had clinical cardiac dysfunction. One patient each on GM-CSF and peg-GCSF developed neutropenic fever. Conclusion: Short course of TCH following response adjusted 2-4 cycles of AC will have an improved therapeutic ratio with minimum cardiac toxicity and maximal response.See the table in the abstract for the inflammatory breast cancer subset.

[edit] External links

Wikipedia's external links policy and the specific guidelines for medicine-related articles do not permit the inclusion of external links to non-encyclopedic material, particularly including: patient support groups, personal experience/survivor stories, internet chat boards, e-mail discussion groups, recruiters for clinical trials, healthcare providers, fundraisers, or similar pages.

Wikipedia is an encyclopedia, not an advertising opportunity or a support group for patients or their families. Please do not re-insert links that do not conform to the standard rules.

External links are not required in Wikipedia articles. They are permitted in limited numbers and in accordance with the policies linked above. If you want to include one or more external links in this article, please link directly to a webpage that provides detailed, encyclopedic information about the disease. Thanks, WhatamIdoing (talk) 02:55, 13 April 2008 (UTC)