Indolepyruvate decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, an indolepyruvate decarboxylase (EC 4.1.1.74) is an enzyme that catalyzes the chemical reaction

3-(indol-3-yl)pyruvate 2-(indol-3-yl)acetaldehyde + CO₂

Hence, this enzyme has one substrate, 3-(indol-3-yl)pyruvate, and two products, 2-(indol-3-yl)acetaldehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]. Other names in common use include indol-3-yl-pyruvate carboxy-lyase, and 3-(indol-3-yl)pyruvate carboxy-lyase. This enzyme participates in tryptophan metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1OVM.

[edit] References

• IUBMB entry for 4.1.1.74
• BRENDA references for 4.1.1.74 (Recommended.)
• PubMed references for 4.1.1.74
• PubMed Central references for 4.1.1.74
• Google Scholar references for 4.1.1.74
• Koga J (1995). "Structure and function of indolepyruvate decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis". Biochim. Biophys. Acta. 1249: 1–13. PMID 7766676. 

[edit] External links

The CAS registry number for this enzyme class is 9074-92-4.

• IUBMB entry for 4.1.1.74

• KEGG entry for 4.1.1.74

• BRENDA entry for 4.1.1.74

• NiceZyme view of 4.1.1.74

• EC2PDB: PDB structures for 4.1.1.74

• PRIAM entry for 4.1.1.74

• PUMA2 entry for 4.1.1.74

• IntEnz: Integrated Enzyme entry for 4.1.1.74

• MetaCyc entry for 4.1.1.74

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047434: indolepyruvate decarboxylase

• AMIGO entry for GO code 0047434: indolepyruvate decarboxylase