Indole 2,3-dioxygenase

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In enzymology, an indole 2,3-dioxygenase (EC 1.13.11.17) is an enzyme that catalyzes the chemical reaction

indole + O₂ $\rightleftharpoons$ 2-formylaminobenzaldehyde

Thus, the two substrates of this enzyme are indole and O₂, whereas its product is 2-formylaminobenzaldehyde.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is indole:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include indole oxidase, indoleamine 2,3-dioxygenase (ambiguous), indole:O2 oxidoreductase, indole-oxygen 2,3-oxidoreductase (decyclizing), and IDO (ambiguous). This enzyme participates in tryptophan metabolism. It has 3 cofactors: copper, Flavin, and Flavoprotein.

[edit] References

IUBMB entry for 1.13.11.17
BRENDA references for 1.13.11.17 (Recommended.)
PubMed references for 1.13.11.17
PubMed Central references for 1.13.11.17
Google Scholar references for 1.13.11.17
Divakar NG, Subramanian V, Sugumaran M and Vaidyanathan CS (1979). "Indole oxygenase from the leaves of Jasminum grandiflorum". Plant Sci. Lett. 15: 177–181. doi:10.1016/0304-4211(79)90071-3.
Kunapuli SP and Vaidyanathan CS (1983). "Purification and characterization of a new indole oxygenase from the leaves of Tecoma stans L". Plant Physiol. 71: 19–23.
Nair PM and Vaidyanathan CS (1964). "An indole oxidase isolated from the leaves of Tecoma stans". Biochim. Biophys. Acta 81: 496–506.