Indole-3-acetaldehyde reductase (NADPH)

From Wikipedia, the free encyclopedia

In enzymology, an indole-3-acetaldehyde reductase (NADPH) (EC 1.1.1.191) is an enzyme that catalyzes the chemical reaction

(indol-3-yl)ethanol + NADP⁺ (indol-3-yl)acetaldehyde + NADPH + H⁺

Thus, the two substrates of this enzyme are (indol-3-yl)ethanol and NADP⁺, whereas its 3 products are (indol-3-yl)acetaldehyde, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (indol-3-yl)ethanol:NADP+ oxidoreductase. Other names in common use include indoleacetaldehyde (reduced nicotinamide adenine dinucleotide, phosphate) reductase, indole-3-acetaldehyde reductase (NADPH), and indole-3-ethanol:NADP+ oxidoreductase. This enzyme participates in tryptophan metabolism.

[edit] References

• IUBMB entry for 1.1.1.191
• BRENDA references for 1.1.1.191 (Recommended.)
• PubMed references for 1.1.1.191
• PubMed Central references for 1.1.1.191
• Google Scholar references for 1.1.1.191
• Brown HM, Purves WK (1976). "Isolation and characterization of indole-3-acetaldehyde reductases from Cucumis sativus". J. Biol. Chem. 251: 907–13. PMID 2607. 

[edit] External links

The CAS registry number for this enzyme class is 58875-05-1.

• IUBMB entry for 1.1.1.191

• KEGG entry for 1.1.1.191

• BRENDA entry for 1.1.1.191

• NiceZyme view of 1.1.1.191

• EC2PDB: PDB structures for 1.1.1.191

• PRIAM entry for 1.1.1.191

• PUMA2 entry for 1.1.1.191

• IntEnz: Integrated Enzyme entry for 1.1.1.191

• MetaCyc entry for 1.1.1.191

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047019: indole-3-acetaldehyde reductase (NADPH)

• AMIGO entry for GO code 0047019: indole-3-acetaldehyde reductase (NADPH)