In vivo selection of an entire exon

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In vivo selection of an entire exon is a powerful technique used by Singh and coworkers to identify novel regulatory elements within an exonic sequence that undergoes alternative splicing [1]. Thanks to in vivo selection of entire exon 7 of SMN gene, many regulatory elements could be identified. A knowledge of such elements are crucial for understanding the underlying cause of Spinal Muscular Atrophy, a devastating neuromuscular genetic disease of children and infants [2].