IMP cyclohydrolase

From Wikipedia, the free encyclopedia

In enzymology, an IMP cyclohydrolase (EC 3.5.4.10) is an enzyme that catalyzes the chemical reaction

IMP + H₂O 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Thus, the two substrates of this enzyme are IMP and H₂O, whereas its product is 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is IMP 1,2-hydrolase (decyclizing). Other names in common use include inosinicase, and inosinate cyclohydrolase. This enzyme participates in purine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1G8M, 1M9N, 1OZ0, 1P4R, 1PKX, 1PL0, 1THZ, 2B1G, 2B1I, 2IU0, 2IU3, 2NTK, 2NTL, and 2NTM.

[edit] References

• IUBMB entry for 3.5.4.10
• BRENDA references for 3.5.4.10 (Recommended.)
• PubMed references for 3.5.4.10
• PubMed Central references for 3.5.4.10
• Google Scholar references for 3.5.4.10
• FLAKS JG, ERWIN MJ, BUCHANAN JM (1957). "Biosynthesis of the purines. XVIII 5-Amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase and inosinicase". J. Biol. Chem. 229: 603–12. PMID 13502325. 

[edit] External links

The CAS registry number for this enzyme class is 9013-81-4.

• IUBMB entry for 3.5.4.10

• KEGG entry for 3.5.4.10

• BRENDA entry for 3.5.4.10

• NiceZyme view of 3.5.4.10

• EC2PDB: PDB structures for 3.5.4.10

• PRIAM entry for 3.5.4.10

• PUMA2 entry for 3.5.4.10

• IntEnz: Integrated Enzyme entry for 3.5.4.10

• MetaCyc entry for 3.5.4.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003937: IMP cyclohydrolase

• AMIGO entry for GO code 0003937: IMP cyclohydrolase