IMPA2

From Wikipedia, the free encyclopedia

Inositol(myo)-1(or 4)-monophosphatase 2

PDB rendering based on 2czh.

Available structures: 2czh, 2czi, 2czk, 2ddk, 2fvz

Identifiers

Symbol(s)

IMPA2;

External IDs

OMIM: 605922 MGI: 2149728 HomoloGene: 22799

Gene ontology
Molecular Function:	• magnesium ion binding • inositol or phosphatidylinositol phosphatase activity • inositol-1(or 4)-monophosphatase activity • hydrolase activity
Biological Process:	• phosphate metabolic process • signal transduction

Orthologs

Human

Mouse

Refseq

NM_014214 (mRNA)
NP_055029 (protein)

NM_053261 (mRNA)
NP_444491 (protein)

Location

Chr 18: 11.97 - 12.02 Mb

Chr 18: 67.41 - 67.44 Mb

Pubmed search

[1]

[2]

Inositol(myo)-1(or 4)-monophosphatase 2, also known as IMPA2, is a human gene.^[1]

[edit] References

^ Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Yoshikawa T, Turner G, Esterling LE, et al. (1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.". Mol. Psychiatry 2 (5): 393–7. PMID 9322233.
Yoshikawa T, Padigaru M, Karkera JD, et al. (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2).". Mol. Psychiatry 5 (2): 165–71. PMID 10822344.
Sjøholt G, Gulbrandsen AK, Løvlie R, et al. (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients.". Mol. Psychiatry 5 (2): 172–80. PMID 10822345.
Yoon IS, Li PP, Siu KP, et al. (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder.". Mol. Psychiatry 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID 11673796.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Azzouz TN, Schumperli D (2004). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster.". RNA 9 (12): 1532–41. PMID 14624008.
Sjøholt G, Ebstein RP, Lie RT, et al. (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder.". Mol. Psychiatry 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID 14699425.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Nakayama J, Yamamoto N, Hamano K, et al. (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18.". Neurology 63 (10): 1803–7. PMID 15557493.
Ohnishi T, Ohba H, Seo KC, et al. (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.
Ohnishi T, Yamada K, Ohba H, et al. (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription.". Neuropsychopharmacology 32 (8): 1727–37. doi:10.1038/sj.npp.1301307. PMID 17251911.
Arai R, Ito K, Ohnishi T, et al. (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures.". Proteins 67 (3): 732–42. doi:10.1002/prot.21299. PMID 17340635.
Blair MA, Ma S, Abou-Khalil B, Hedera P (2007). "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients.". Eur. J. Neurol. 14 (4): 424–7. doi:10.1111/j.1468-1331.2007.01702.x. PMID 17388992.