ILKAP

From Wikipedia, the free encyclopedia

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Identifiers

ILKAP; PP2C-DELTA; DKFZP434J2031; FLJ10181; MGC4846

External IDs

MGI: 1914694 HomoloGene: 31525

Gene ontology
Molecular Function:	• magnesium ion binding • protein serine/threonine phosphatase activity • hydrolase activity • manganese ion binding
Cellular Component:	• protein serine/threonine phosphatase complex
Biological Process:	• protein amino acid dephosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030768 (mRNA)
NP_110395 (protein)

NM_023343 (mRNA)
NP_075832 (protein)

Location

Chr 2: 238.74 - 238.78 Mb

Chr 1: 93.21 - 93.23 Mb

Pubmed search

[1]

[2]

Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a human gene.^[1]

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C.

[edit] Further reading

Tong Y, Quirion R, Shen SH (1999). "Cloning and characterization of a novel mammalian PP2C isozyme.". J. Biol. Chem. 273 (52): 35282–90. PMID 9857069.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.". EMBO J. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMID 11331582.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kumar AS, Naruszewicz I, Wang P, et al. (2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth.". Oncogene 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.