IL2RA

From Wikipedia, the free encyclopedia

Interleukin 2 receptor, alpha

PDB rendering based on 1z92.

Available structures: 1z92, 2b5i, 2erj

Identifiers

Symbol(s)

IL2RA; IDDM10; CD25; IL2R; TCGFR

External IDs

OMIM: 147730 MGI: 96549 HomoloGene: 360

Gene ontology
Molecular Function:	• receptor activity • interleukin-2 receptor activity
Cellular Component:	• plasma membrane • external side of plasma membrane • integral to membrane
Biological Process:	• regulation of progression through cell cycle • activated T cell apoptosis • immune response • cell surface receptor linked signal transduction • cell proliferation • positive regulation of activated T cell proliferation • negative regulation of T cell proliferation • positive regulation of apoptosis • negative regulation of inflammatory response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000417 (mRNA)
NP_000408 (protein)

XM_993137 (mRNA)
XP_998231 (protein)

Location

Chr 10: 6.09 - 6.14 Mb

Chr 2: 11.56 - 11.61 Mb

Pubmed search

[1]

[2]

Interleukin 2 receptor, alpha, also known as IL2RA, is a human gene.

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown.^[1]

[edit] References

^ Entrez Gene: IL2RA interleukin 2 receptor, alpha.

[edit] Further reading

Kuziel WA, Greene WC (1990). "Interleukin-2 and the IL-2 receptor: new insights into structure and function.". J. Invest. Dermatol. 94 (6 Suppl): 27S–32S. PMID 1693645.
Waldmann TA (1991). "The interleukin-2 receptor.". J. Biol. Chem. 266 (5): 2681–4. PMID 1993646.
Murakami S (2006). "Soluble interleukin-2 receptor in cancer.". Front. Biosci. 9: 3085–90. PMID 15353339.
Vincenti F (2005). "Interleukin-2 receptor antagonists and aggressive steroid minimization strategies for kidney transplant patients.". Transpl. Int. 17 (8): 395–401. doi:10.1007/s00147-004-0750-3. PMID 15365604.