IL25

From Wikipedia, the free encyclopedia


Interleukin 25
Identifiers
Symbol(s) IL25; IL-17E; IL-25; IL17E
External IDs OMIM: 605658 MGI2155888 HomoloGene15429
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 64806 140806
Ensembl ENSG00000166090 ENSMUSG00000040770
Uniprot Q9H293 n/a
Refseq NM_022789 (mRNA)
NP_073626 (protein)
NM_080729 (mRNA)
NP_542767 (protein)
Location Chr 14: 22.91 - 22.92 Mb Chr 14: 53.89 - 53.89 Mb
Pubmed search [1] [2]

Interleukin 25, also known as IL25, is a human gene.[1]

The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-kappaB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17BR. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[1]

[edit] References

[edit] Further reading

  • Lee J, Ho WH, Maruoka M, et al. (2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.". J. Biol. Chem. 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597. 
  • Pan G, French D, Mao W, et al. (2002). "Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice.". J. Immunol. 167 (11): 6559–67. PMID 11714825. 
  • Fort MM, Cheung J, Yen D, et al. (2002). "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.". Immunity 15 (6): 985–95. PMID 11754819. 
  • Kim MR, Manoukian R, Yeh R, et al. (2002). "Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.". Blood 100 (7): 2330–40. doi:10.1182/blood-2002-01-0012. PMID 12239140. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Létuvé S, Lajoie-Kadoch S, Audusseau S, et al. (2006). "IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.". J. Allergy Clin. Immunol. 117 (3): 590–6. doi:10.1016/j.jaci.2005.10.025. PMID 16522458. 
  • Tamachi T, Maezawa Y, Ikeda K, et al. (2006). "IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice.". J. Allergy Clin. Immunol. 118 (3): 606–14. doi:10.1016/j.jaci.2006.04.051. PMID 16950278. 
  • Wang YH, Angkasekwinai P, Lu N, et al. (2007). "IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.". J. Exp. Med. 204 (8): 1837–47. doi:10.1084/jem.20070406. PMID 17635955.