IL1RAPL2

From Wikipedia, the free encyclopedia

Interleukin 1 receptor accessory protein-like 2

Identifiers

IL1RAPL2; IL-1R9; IL1R9; IL1RAPL-2; TIGIRR-1

External IDs

OMIM: 300277 MGI: 1913106 HomoloGene: 9681

Gene ontology
Molecular Function:	• transmembrane receptor activity • interleukin-1, Type II, blocking receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• central nervous system development

Orthologs

Human

Mouse

Refseq

NM_017416 (mRNA)
NP_059112 (protein)

NM_030688 (mRNA)
NP_109613 (protein)

Location

Chr X: 103.7 - 104.9 Mb

Chr X: 133 - 134.19 Mb

Pubmed search

[1]

[2]

Interleukin 1 receptor accessory protein-like 2, also known as IL1RAPL2, is a human gene.^[1]

The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation.^[1]

[edit] References

^ ^a ^b Entrez Gene: IL1RAPL2 interleukin 1 receptor accessory protein-like 2.

[edit] Further reading

Grundtman C, Salomonsson S, Dorph C, et al. (2007). "Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies.". Arthritis Rheum. 56 (2): 674-87. doi:10.1002/art.22388. PMID 17265504.
Libra M, Mangano K, Anzaldi M, et al. (2006). "Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders.". Oncol. Rep. 15 (5): 1305-8. PMID 16596202.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ferrante MI, Ghiani M, Bulfone A, Franco B (2001). "IL1RAPL2 maps to Xq22 and is specifically expressed in the central nervous system.". Gene 275 (2): 217-21. PMID 11587848.
Sana TR, Debets R, Timans JC, et al. (2001). "Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3.". Genomics 69 (2): 252-62. doi:10.1006/geno.2000.6328. PMID 11031108.
Born TL, Smith DE, Garka KE, et al. (2000). "Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling.". J. Biol. Chem. 275 (39): 29946-54. doi:10.1074/jbc.M004077200. PMID 10882729.
Jin H, Gardner RJ, Viswesvaraiah R, et al. (2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation.". Eur. J. Hum. Genet. 8 (2): 87-94. doi:10.1038/sj.ejhg.5200415. PMID 10757639.
Nagaoka H, Ozawa K, Matsuda F, et al. (1994). "Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16.". Genomics 22 (1): 189-97. PMID 7959766.