IL1F8

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Interleukin 1 family, member 8 (eta)
Identifiers
Symbol(s) IL1F8; FIL1; FIL1-(ETA); FIL1H; IL-1F8; IL-1H2; IL1-ETA; IL1H2; MGC126880; MGC126882
External IDs OMIM: 605508 MGI: 1916927 HomoloGene: 18278
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 27177 69677
Ensembl ENSG00000136696 ENSMUSG00000026985
Uniprot Q9NZH7 Q08EA6
Refseq NM_014438 (mRNA)
NP_055253 (protein)		 XM_130058 (mRNA)
XP_130058 (protein)
Location Chr 2: 113.5 - 113.53 Mb Chr 2: 23.98 - 23.98 Mb
Pubmed search [1] [2]

Interleukin 1 family, member 8 (eta), also known as IL1F8, is a human gene.[1]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: IL1F8 interleukin 1 family, member 8 (eta).

[edit] Further reading

  • Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes.". Genomics 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271. 
  • Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.". Genomics 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134. 
  • Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene.". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  • Smith DE, Renshaw BR, Ketchem RR, et al. (2000). "Four new members expand the interleukin-1 superfamily.". J. Biol. Chem. 275 (2): 1169–75. PMID 10625660. 
  • Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family.". J. Biol. Chem. 275 (14): 10308–14. PMID 10744718. 
  • Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666. 
  • Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.". Eur. J. Immunol. 30 (11): 3299–308. PMID 11093146. 
  • Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.". Cytokine 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836. 
  • Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614. 
  • Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.". J. Immunol. 167 (3): 1440–6. PMID 11466363. 
  • Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes.". Trends Immunol. 22 (10): 536–7. PMID 11574262. 
  • Nicklin MJ, Barton JL, Nguyen M, et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster.". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  • Magne D, Palmer G, Barton JL, et al. (2006). "The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.". Arthritis Res. Ther. 8 (3): R80. doi:10.1186/ar1946. PMID 16646978. 
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