IL1F5

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Interleukin 1 family, member 5 (delta)
PDB rendering based on 1md6.
Available structures: 1md6
Identifiers
Symbol(s) IL1F5; FIL1; FIL1(DELTA); FIL1D; IL1HY1; IL1L1; IL1RP3; MGC29840
External IDs OMIM: 605507 MGI: 1859325 HomoloGene: 10453
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 26525 54450
Ensembl ENSG00000136695 ENSMUSG00000026983
Uniprot Q9UBH0 Q9QYY1
Refseq NM_012275 (mRNA)
NP_036407 (protein)		 NM_019451 (mRNA)
NP_062324 (protein)
Location Chr 2: 113.53 - 113.54 Mb Chr 2: 24.1 - 24.11 Mb
Pubmed search [1] [2]

Interleukin 1 family, member 5 (delta), also known as IL1F5, is a human gene.[1]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: IL1F5 interleukin 1 family, member 5 (delta).

[edit] Further reading

  • Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes.". Genomics 19 (2): 382-4. doi:10.1006/geno.1994.1076. PMID 8188271. 
  • Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.". Genomics 41 (3): 370-8. doi:10.1006/geno.1997.4654. PMID 9169134. 
  • Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene.". Biochem. Biophys. Res. Commun. 263 (3): 702-6. doi:10.1006/bbrc.1999.1440. PMID 10512743. 
  • Smith DE, Renshaw BR, Ketchem RR, et al. (2000). "Four new members expand the interleukin-1 superfamily.". J. Biol. Chem. 275 (2): 1169-75. PMID 10625660. 
  • Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family.". J. Biol. Chem. 275 (14): 10308-14. PMID 10744718. 
  • Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.". Genomics 66 (2): 213-6. doi:10.1006/geno.2000.6184. PMID 10860666. 
  • Mulero JJ, Nelken ST, Ford JE (2000). "Organization of the human interleukin-1 receptor antagonist gene IL1HY1.". Immunogenetics 51 (6): 425-8. PMID 10866108. 
  • Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.". Eur. J. Immunol. 30 (11): 3299-308. PMID 11093146. 
  • Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.". Cytokine 13 (1): 1-7. doi:10.1006/cyto.2000.0799. PMID 11145836. 
  • Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597-602. doi:10.1074/jbc.M010095200. PMID 11278614. 
  • Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.". J. Immunol. 167 (3): 1440-6. PMID 11466363. 
  • Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes.". Trends Immunol. 22 (10): 536-7. PMID 11574262. 
  • Tazi-Ahnini R, Cox A, McDonagh AJ, et al. (2002). "Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction.". Eur. J. Immunogenet. 29 (1): 25-30. PMID 11841485. 
  • Nicklin MJ, Barton JL, Nguyen M, et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster.". Genomics 79 (5): 718-25. doi:10.1006/geno.2002.6751. PMID 11991722. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Zee RY, Fernandez-Ortiz A, Macaya C, et al. (2004). "IL-1 cluster genes and occurrence of post-percutaneous transluminal coronary angioplasty restenosis: a prospective, angiography-based evaluation.". Atherosclerosis 171 (2): 259-64. PMID 14644395. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
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