From Wikipedia, the free encyclopedia
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Interleukin 1, beta
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| PDB rendering based on 31bi. |
| Available structures: 1hib, 1i1b, 1iob, 1itb, 1l2h, 1s0l, 1t4q, 1too, 1tp0, 1twe, 1twm, 21bi, 2i1b, 2nvh, 31bi, 41bi, 4i1b, 5i1b, 6i1b, 7i1b, 9ilb |
| Identifiers |
| Symbol(s) |
IL1B; IL-1; IL1-BETA; IL1F2 |
| External IDs |
OMIM: 147720 MGI: 96543 HomoloGene: 481 |
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| RNA expression pattern |
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More reference expression data
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| Orthologs |
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Human |
Mouse |
| Entrez |
3553 |
16176 |
| Ensembl |
ENSG00000125538 |
ENSMUSG00000027398 |
| Uniprot |
P01584 |
Q2M4J6 |
| Refseq |
NM_000576 (mRNA)
NP_000567 (protein) |
NM_008361 (mRNA)
NP_032387 (protein) |
| Location |
Chr 2: 113.3 - 113.31 Mb |
Chr 2: 129.06 - 129.06 Mb |
| Pubmed search |
[1] |
[2] |
Interleukin 1, beta, also known as IL1B, is a human gene. Interleukin-1 beta is a cytokine. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.[1]
[edit] See also
[edit] References
[edit] Further reading
- Smirnova MG, Kiselev SL, Gnuchev NV, et al. (2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion.". Eur. Cytokine Netw. 13 (2): 161–72. PMID 12101072.
- Griffin WS, Mrak RE (2002). "Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease.". J. Leukoc. Biol. 72 (2): 233–8. PMID 12149413.
- Arend WP (2003). "The balance between IL-1 and IL-1Ra in disease.". Cytokine Growth Factor Rev. 13 (4-5): 323–40. PMID 12220547.
- Chakravorty M, Ghosh A, Choudhury A, et al. (2004). "Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India.". Hum. Biol. 76 (1): 153–9. PMID 15222686.
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726.
- Maruyama Y, Stenvinkel P, Lindholm B (2005). "Role of interleukin-1beta in the development of malnutrition in chronic renal failure patients.". Blood Purif. 23 (4): 275–81. doi:10.1159/000086012. PMID 15925866.
- Roy D, Sarkar S, Felty Q (2006). "Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells.". Front. Biosci. 11: 889–98. PMID 16146780.
- Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093–101. PMID 16375755.
- Prinz C, Schwendy S, Voland P (2006). "H pylori and gastric cancer: shifting the global burden.". World J. Gastroenterol. 12 (34): 5458–64. PMID 17006981.
- Kamangar F, Cheng C, Abnet CC, Rabkin CS (2007). "Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis.". Cancer Epidemiol. Biomarkers Prev. 15 (10): 1920–8. doi:10.1158/1055-9965.EPI-06-0267. PMID 17035400.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
