IL17A

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Interleukin 17A
Identifiers
Symbol(s) IL17A; CTLA8; IL-17; IL-17A; IL17
External IDs OMIM: 603149 MGI: 107364 HomoloGene: 1651
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3605 16171
Ensembl ENSG00000112115 ENSMUSG00000025929
Uniprot Q16552 Q544E6
Refseq NM_002190 (mRNA)
NP_002181 (protein)		 NM_010552 (mRNA)
NP_034682 (protein)
Location Chr 6: 52.16 - 52.16 Mb Chr 1: 20.72 - 20.72 Mb
Pubmed search [1] [2]

Interleukin 17A, also known as IL17A, is a human gene.[1]

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: IL17A interleukin 17A.

[edit] Further reading

  • Gaffen SL (2005). "Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.". Arthritis Res. Ther. 6 (6): 240-7. doi:10.1186/ar1444. PMID 15535837. 
  • Lubberts E, Koenders MI, van den Berg WB (2006). "The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.". Arthritis Res. Ther. 7 (1): 29-37. doi:10.1186/ar1478. PMID 15642151. 
  • Yao Z, Painter SL, Fanslow WC, et al. (1996). "Human IL-17: a novel cytokine derived from T cells.". J. Immunol. 155 (12): 5483-6. PMID 7499828. 
  • Rouvier E, Luciani MF, Mattéi MG, et al. (1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.". J. Immunol. 150 (12): 5445-56. PMID 8390535. 
  • Fossiez F, Djossou O, Chomarat P, et al. (1996). "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.". J. Exp. Med. 183 (6): 2593-603. PMID 8676080. 
  • Yao Z, Spriggs MK, Derry JM, et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor.". Cytokine 9 (11): 794-800. PMID 9367539. 
  • Murphy KP, Gagne P, Pazmany C, Moody MD (1998). "Expression of human interleukin-17 in Pichia pastoris: purification and characterization.". Protein Expr. Purif. 12 (2): 208-14. doi:10.1006/prep.1997.0832. PMID 9518462. 
  • Teunissen MB, Koomen CW, de Waal Malefyt R, et al. (1998). "Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.". J. Invest. Dermatol. 111 (4): 645-9. doi:10.1046/j.1523-1747.1998.00347.x. PMID 9764847. 
  • Shalom-Barak T, Quach J, Lotz M (1998). "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.". J. Biol. Chem. 273 (42): 27467-73. PMID 9765276. 
  • Shin HC, Benbernou N, Fekkar H, et al. (1999). "Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway.". Cytokine 10 (11): 841-50. doi:10.1006/cyto.1998.0375. PMID 9878122. 
  • Laan M, Cui ZH, Hoshino H, et al. (1999). "Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.". J. Immunol. 162 (4): 2347-52. PMID 9973514. 
  • Kotake S, Udagawa N, Takahashi N, et al. (1999). "IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.". J. Clin. Invest. 103 (9): 1345-52. PMID 10225978. 
  • Shin HC, Benbernou N, Esnault S, Guenounou M (1999). "Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.". Cytokine 11 (4): 257-66. doi:10.1006/cyto.1998.0433. PMID 10328864. 
  • Andoh A, Takaya H, Makino J, et al. (2001). "Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells.". Clin. Exp. Immunol. 125 (1): 56-63. PMID 11472426. 
  • Laan M, Palmberg L, Larsson K, Lindén A (2002). "Free, soluble interleukin-17 protein during severe inflammation in human airways.". Eur. Respir. J. 19 (3): 534-7. PMID 11936535. 
  • Andoh A, Fujino S, Bamba S, et al. (2002). "IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts.". J. Immunol. 169 (4): 1683-7. PMID 12165487. 
  • Andoh A, Shimada M, Bamba S, et al. (2002). "Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts.". Biochim. Biophys. Acta 1591 (1-3): 69-74. PMID 12183057. 
  • Hsieh HG, Loong CC, Lin CY (2003). "Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells.". Cytokine 19 (4): 159-74. PMID 12297109. 
  • Aggarwal S, Ghilardi N, Xie MH, et al. (2003). "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.". J. Biol. Chem. 278 (3): 1910-4. doi:10.1074/jbc.M207577200. PMID 12417590. 
  • Maertzdorf J, Osterhaus AD, Verjans GM (2003). "IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.". J. Immunol. 169 (10): 5897-903. PMID 12421973. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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