IL13RA2
From Wikipedia, the free encyclopedia
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Interleukin 13 receptor, alpha 2
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| Identifiers | |||||||||||
| Symbol(s) | IL13RA2; CD213A2; IL-13R; IL13BP | ||||||||||
| External IDs | OMIM: 300130 MGI: 1277954 HomoloGene: 534 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 3598 | 16165 | |||||||||
| Ensembl | ENSG00000123496 | ENSMUSG00000031289 | |||||||||
| Uniprot | Q14627 | n/a | |||||||||
| Refseq | NM_000640 (mRNA) NP_000631 (protein) |
NM_008356 (mRNA) NP_032382 (protein) |
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| Location | Chr X: 114.14 - 114.16 Mb | Chr X: 142.63 - 142.68 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Interleukin 13 receptor, alpha 2, also known as IL13RA2 and CD213A2 (cluster of differentiation 213A2), is a human gene.[1]
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.[1]
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[edit] See also
[edit] References
[edit] Further reading
- Caput D, Laurent P, Kaghad M, et al. (1996). "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain.". J. Biol. Chem. 271 (28): 16921–6. PMID 8663118.
- Zhang JG, Hilton DJ, Willson TA, et al. (1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains.". J. Biol. Chem. 272 (14): 9474–80. PMID 9083087.
- Gauchat JF, Schlagenhauf E, Feng NP, et al. (1997). "A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor.". Eur. J. Immunol. 27 (4): 971–8. PMID 9130652.
- Guo J, Apiou F, Mellerin MP, et al. (1997). "Chromosome mapping and expression of the human interleukin-13 receptor.". Genomics 42 (1): 141–5. doi:. PMID 9177784.
- Donaldson DD, Whitters MJ, Fitz LJ, et al. (1998). "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1.". J. Immunol. 161 (5): 2317–24. PMID 9725226.
- Osawa M, Miyoshi S, Copeland NG, et al. (2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene.". Immunogenetics 51 (11): 974–81. PMID 11003391.
- Kawakami K, Takeshita F, Puri RK (2001). "Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain.". J. Biol. Chem. 276 (27): 25114–20. doi:. PMID 11352909.
- Daines MO, Hershey GK (2002). "A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma.". J. Biol. Chem. 277 (12): 10387–93. doi:. PMID 11786536.
- Okano F, Storkus WJ, Chambers WH, et al. (2002). "Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain.". Clin. Cancer Res. 8 (9): 2851–5. PMID 12231526.
- Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, et al. (2003). "Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein.". J. Invest. Dermatol. 119 (5): 1114–20. doi:. PMID 12445201.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- David M, Bertoglio J, Pierre J (2003). "TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression.". Ann. N. Y. Acad. Sci. 973: 207–9. PMID 12485861.
- Wu AH, Low WC (2003). "Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter.". Neuro-oncology 5 (3): 179–87. doi:. PMID 12816724.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:. PMID 15772651.
- Arima K, Sato K, Tanaka G, et al. (2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors.". J. Biol. Chem. 280 (26): 24915–22. doi:. PMID 15870068.
- Fichtner-Feigl S, Strober W, Kawakami K, et al. (2006). "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.". Nat. Med. 12 (1): 99–106. doi:. PMID 16327802.
- Daines MO, Tabata Y, Walker BA, et al. (2006). "Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling.". J. Immunol. 176 (12): 7495–501. PMID 16751396.
- Kioi M, Kawakami M, Shimamura T, et al. (2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy.". Cancer 107 (6): 1407–18. doi:. PMID 16902988.
- Granel B, Allanore Y, Chevillard C, et al. (2007). "IL13RA2 gene polymorphisms are associated with systemic sclerosis.". J. Rheumatol. 33 (10): 2015–9. PMID 16981293.
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