IKZF1

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IKAROS family zinc finger 1 (Ikaros)
Identifiers
Symbol(s) IKZF1; IK1; Hs.54452; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1
External IDs OMIM: 603023 MGI: 1342540 HomoloGene: 55948
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10320 22778
Ensembl ENSG00000185811 ENSMUSG00000018654
Uniprot Q13422 Q5GGW4
Refseq NM_006060 (mRNA)
NP_006051 (protein)		 NM_001025597 (mRNA)
NP_001020768 (protein)
Location Chr 7: 50.31 - 50.44 Mb Chr 11: 11.59 - 11.67 Mb
Pubmed search [1] [2]

IKAROS family zinc finger 1 (Ikaros), also known as IKZF1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros).

[edit] Further reading

  • Tonnelle C, Calmels B, Maroc C, et al. (2003). "Ikaros gene expression and leukemia.". Leuk. Lymphoma 43 (1): 29-35. PMID 11908734. 
  • Westman BJ, Mackay JP, Gell D (2002). "Ikaros: a key regulator of haematopoiesis.". Int. J. Biochem. Cell Biol. 34 (10): 1304-7. PMID 12127581. 
  • Georgopoulos K, Moore DD, Derfler B (1992). "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment.". Science 258 (5083): 808-12. PMID 1439790. 
  • Hahm K, Ernst P, Lo K, et al. (1994). "The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.". Mol. Cell. Biol. 14 (11): 7111-23. PMID 7935426. 
  • Molnár A, Wu P, Largespada DA, et al. (1996). "The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse.". J. Immunol. 156 (2): 585-92. PMID 8543809. 
  • Nietfeld W, Meyerhans A (1996). "Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1.". Immunol. Lett. 49 (1-2): 139-41. PMID 8964602. 
  • Morgan B, Sun L, Avitahl N, et al. (1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.". EMBO J. 16 (8): 2004-13. doi:10.1093/emboj/16.8.2004. PMID 9155026. 
  • Kelley CM, Ikeda T, Koipally J, et al. (1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.". Curr. Biol. 8 (9): 508-15. PMID 9560339. 
  • Sun L, Heerema N, Crotty L, et al. (1999). "Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 680-5. PMID 9892693. 
  • Kim J, Sif S, Jones B, et al. (1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.". Immunity 10 (3): 345-55. PMID 10204490. 
  • Honma Y, Kiyosawa H, Mori T, et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system.". FEBS Lett. 447 (1): 76-80. PMID 10218586. 
  • Koipally J, Renold A, Kim J, Georgopoulos K (1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.". EMBO J. 18 (11): 3090-100. doi:10.1093/emboj/18.11.3090. PMID 10357820. 
  • Sun L, Goodman PA, Wood CM, et al. (2000). "Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.". J. Clin. Oncol. 17 (12): 3753-66. PMID 10577847. 
  • Hosokawa Y, Maeda Y, Ichinohasama R, et al. (2000). "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma.". Blood 95 (8): 2719-21. PMID 10753856. 
  • Koipally J, Georgopoulos K (2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.". J. Biol. Chem. 275 (26): 19594-602. doi:10.1074/jbc.M000254200. PMID 10766745. 
  • Perdomo J, Holmes M, Chong B, Crossley M (2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.". J. Biol. Chem. 275 (49): 38347-54. doi:10.1074/jbc.M005457200. PMID 10978333. 
  • Payne KJ, Nicolas JH, Zhu JY, et al. (2001). "Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis.". J. Immunol. 167 (4): 1867-70. PMID 11489963. 
  • Koipally J, Heller EJ, Seavitt JR, Georgopoulos K (2002). "Unconventional potentiation of gene expression by Ikaros.". J. Biol. Chem. 277 (15): 13007-15. doi:10.1074/jbc.M111371200. PMID 11799125. 
  • Dorsam G, Goetzl EJ (2002). "Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros.". J. Biol. Chem. 277 (16): 13488-93. doi:10.1074/jbc.M107922200. PMID 11812772. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD