IKBKE

From Wikipedia, the free encyclopedia

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Identifiers

IKBKE; IKK-i; IKKE; IKKI; KIAA0151; MGC125294; MGC125295; MGC125297

External IDs

OMIM: 605048 MGI: 1929612 HomoloGene: 23168

Gene ontology
Molecular Function:	• nucleotide binding • NF-kappaB-inducing kinase activity • signal transducer activity • protein binding • ATP binding • IkappaB kinase activity • transferase activity
Cellular Component:	• cytoplasm
Biological Process:	• protein amino acid phosphorylation • immune response • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014002 (mRNA)
NP_054721 (protein)

NM_019777 (mRNA)
NP_062751 (protein)

Location

Chr 1: 204.71 - 204.74 Mb

Chr 1: 133.08 - 133.11 Mb

Pubmed search

[1]

[2]

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, also known as IKBKE, is a human gene.^[1]

[edit] References

^ Entrez Gene: IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.

[edit] Further reading

Mercurio AM (2003). "Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way.". Cancer Cell 3 (3): 201–2. PMID 12676577.
Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280.
Shimada T, Kawai T, Takeda K, et al. (1999). "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.". Int. Immunol. 11 (8): 1357–62. PMID 10421793.
Nomura F, Kawai T, Nakanishi K, Akira S (2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.". Genes Cells 5 (3): 191–202. PMID 10759890.
Peters RT, Liao SM, Maniatis T (2000). "IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex.". Mol. Cell 5 (3): 513–22. PMID 10882136.
Miller BS, Zandi E (2001). "Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.". J. Biol. Chem. 276 (39): 36320–6. doi:10.1074/jbc.M104051200. PMID 11470787.
Kishore N, Huynh QK, Mathialagan S, et al. (2002). "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.". J. Biol. Chem. 277 (16): 13840–7. doi:10.1074/jbc.M110474200. PMID 11839743.
Aupperle KR, Yamanishi Y, Bennett BL, et al. (2002). "Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes.". Cell. Immunol. 214 (1): 54–9. doi:10.1006/cimm.2002.1885. PMID 11902829.
Bossis G, Salinas S, Cartier C, et al. (2002). "NF-kappaB activation upon interaction of HIV-1 envelope glycoproteins with cell surface CD4 involves IkappaB kinases.". FEBS Lett. 516 (1-3): 257–64. PMID 11959143.
Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fitzgerald KA, McWhirter SM, Faia KL, et al. (2003). "IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.". Nat. Immunol. 4 (5): 491–6. doi:10.1038/ni921. PMID 12692549.
Kravchenko VV, Mathison JC, Schwamborn K, et al. (2003). "IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.". J. Biol. Chem. 278 (29): 26612–9. doi:10.1074/jbc.M303001200. PMID 12736252.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Fujita F, Taniguchi Y, Kato T, et al. (2003). "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.". Mol. Cell. Biol. 23 (21): 7780–93. PMID 14560022.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
tenOever BR, Sharma S, Zou W, et al. (2004). "Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.". J. Virol. 78 (19): 10636–49. doi:10.1128/JVI.78.19.10636-10649.2004. PMID 15367631.
Buss H, Dörrie A, Schmitz ML, et al. (2005). "Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.". J. Biol. Chem. 279 (53): 55633-43. doi:10.1074/jbc.M409825200. PMID 15489227.