IHPK1

From Wikipedia, the free encyclopedia

Inositol hexaphosphate kinase 1

Identifiers

IHPK1; IP6K1; MGC9925; PiUS

External IDs

OMIM: 606991 MGI: 1351633 HomoloGene: 56602

Gene ontology
Molecular Function:	• protein binding • inositol trisphosphate 3-kinase activity • kinase activity • transferase activity • inositol hexakisphosphate kinase activity
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• vesicle-mediated transport • phosphorylation • release of sequestered calcium ion into cytosol

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001006115 (mRNA)
NP_001006115 (protein)

NM_013785 (mRNA)
NP_038813 (protein)

Location

Chr 3: 49.74 - 49.8 Mb

Chr 9: 107.86 - 107.91 Mb

Pubmed search

[1]

[2]

Inositol hexaphosphate kinase 1, also known as IHPK1, is a human gene.^[1]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: IHPK1 inositol hexaphosphate kinase 1.

[edit] Further reading

Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
White KE, Econs MJ (1998). "Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3.". Somat. Cell Mol. Genet. 24 (1): 71–4. PMID 9776982.
Schell MJ, Letcher AJ, Brearley CA, et al. (1999). "PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase.". FEBS Lett. 461 (3): 169–72. PMID 10567691.
Saiardi A, Erdjument-Bromage H, Snowman AM, et al. (2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.". Curr. Biol. 9 (22): 1323–6. PMID 10574768.
Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000). "The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis.". J. Biol. Chem. 275 (32): 24686–92. doi:10.1074/jbc.M002750200. PMID 10827188.
Saiardi A, Nagata E, Luo HR, et al. (2001). "Identification and characterization of a novel inositol hexakisphosphate kinase.". J. Biol. Chem. 276 (42): 39179–85. doi:10.1074/jbc.M106842200. PMID 11502751.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kamimura J, Wakui K, Kadowaki H, et al. (2004). "The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus.". J. Hum. Genet. 49 (7): 360–5. doi:10.1007/s10038-004-0158-z. PMID 15221640.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.