IGHV@

From Wikipedia, the free encyclopedia

Immunoglobulin heavy variable group

Identifiers

External IDs

Gene ontology
Molecular Function:	• antigen binding
Cellular Component:	• extracellular region
Biological Process:	• immune response

Orthologs

Human

Mouse

Entrez

3509

n/a

Pubmed search

[1]

n/a

Immunoglobulin heavy variable group, also known as IGHV@, is a human gene.^[1]

[edit] References

^ Entrez Gene: IGHV@ immunoglobulin heavy variable group.

[edit] Further reading

Walter MA, Dosch HM, Cox DW (1991). "A deletion map of the human immunoglobulin heavy chain variable region.". J. Exp. Med. 174 (2): 335–49. PMID 1649888.
Matsuda F, Shin EK, Hirabayashi Y, et al. (1990). "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments.". EMBO J. 9 (8): 2501–6. PMID 2114977.
Cherif D, Berger R (1991). "New localizations of VH sequences by in situ hybridization with biotinylated probes.". Genes Chromosomes Cancer 2 (2): 103–8. PMID 2126193.
Schroeder HW, Walter MA, Hofker MH, et al. (1988). "Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements.". Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8196–200. PMID 3141924.
Toyonaga B, Yoshikai Y, Vadasz V, et al. (1986). "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain.". Proc. Natl. Acad. Sci. U.S.A. 82 (24): 8624–8. PMID 3866244.
Matthyssens G, Rabbitts TH (1981). "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.". Proc. Natl. Acad. Sci. U.S.A. 77 (11): 6561–5. PMID 6450418.
Mariette X, Tsapis A, Brouet JC (1993). "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein.". Eur. J. Immunol. 23 (4): 846–51. PMID 7681398.
Boursier L, Su W, Spencer J (2003). "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments.". Mol. Immunol. 39 (16): 1025–34. PMID 12749909.
Nakamura N, Nakamura S, Yamaguchi M, et al. (2005). "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region.". Int. J. Hematol. 81 (1): 58–61. PMID 15717690.
Suárez E, Magadán S, Sanjuán I, et al. (2006). "Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice.". Mol. Immunol. 43 (11): 1827–35. doi:10.1016/j.molimm.2005.10.015. PMID 16343622.
Balogh Z, Reiniger L, Deák L, et al. (2007). "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL).". Hematological oncology 25 (2): 90–5. doi:10.1002/hon.812. PMID 17410523.