IGFBP7

From Wikipedia, the free encyclopedia

Insulin-like growth factor binding protein 7

Identifiers

IGFBP7; FSTL2; IGFBP-7; IGFBP-7v; MAC25; PSF

External IDs

OMIM: 602867 MGI: 1352480 HomoloGene: 1193

Gene ontology
Molecular Function:	• insulin-like growth factor binding
Cellular Component:	• extracellular region
Biological Process:	• regulation of cell growth • negative regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001553 (mRNA)
NP_001544 (protein)

NM_008048 (mRNA)
NP_032074 (protein)

Location

Chr 4: 57.59 - 57.67 Mb

Chr 5: 78.42 - 78.48 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor binding protein 7, also known as IGFBP7, is a human gene.^[1]

[edit] References

^ Entrez Gene: IGFBP7 insulin-like growth factor binding protein 7.

[edit] Further reading

Swisshelm K, Ryan K, Tsuchiya K, Sager R (1995). "Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid.". Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4472–6. PMID 7538673.
Murphy M, Pykett MJ, Harnish P, et al. (1993). "Identification and characterization of genes differentially expressed in meningiomas.". Cell Growth Differ. 4 (9): 715–22. PMID 7694637.
Yamauchi T, Umeda F, Masakado M, et al. (1994). "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells.". Biochem. J. 303 ( Pt 2): 591–8. PMID 7980422.
Oh Y, Nagalla SR, Yamanaka Y, et al. (1997). "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.". J. Biol. Chem. 271 (48): 30322–5. PMID 8939990.
Wilson EM, Oh Y, Rosenfeld RG (1997). "Generation and characterization of an IGFBP-7 antibody: identification of 31kD IGFBP-7 in human biological fluids and Hs578T human breast cancer conditioned media.". J. Clin. Endocrinol. Metab. 82 (4): 1301–3. PMID 9100611.
Sekiguchi N, Umeda F, Masakado M, et al. (1997). "Immunohistochemical study of prostacyclin-stimulating factor (PSF) in the diabetic and atherosclerotic human coronary artery.". Diabetes 46 (10): 1627–32. PMID 9313760.
Yamanaka Y, Wilson EM, Rosenfeld RG, Oh Y (1998). "Inhibition of insulin receptor activation by insulin-like growth factor binding proteins.". J. Biol. Chem. 272 (49): 30729–34. PMID 9388210.
Sato J, Hasegawa S, Akaogi K, et al. (1999). "Identification of cell-binding site of angiomodulin (AGM/TAF/Mac25) that interacts with heparan sulfates on cell surface.". J. Cell. Biochem. 75 (2): 187–95. PMID 10502291.
Girard JP, Baekkevold ES, Yamanaka T, et al. (1999). "Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization.". Am. J. Pathol. 155 (6): 2043–55. PMID 10595934.
Degeorges A, Wang F, Frierson HF, et al. (2000). "Distribution of IGFBP-rP1 in normal human tissues.". J. Histochem. Cytochem. 48 (6): 747–54. PMID 10820148.
Kato MV (2000). "A secreted tumor-suppressor, mac25, with activin-binding activity.". Mol. Med. 6 (2): 126–35. PMID 10859029.
Allen JT, Bloor CA, Kedia RK, et al. (2001). "Expression of growth hormone-releasing factor, growth hormone, insulin-like growth factor-1 and its binding proteins in human lung.". Neuropeptides 34 (2): 98–107. doi:10.1054/npep.2000.0802. PMID 10985926.
Wilson EM, Oh Y, Hwa V, Rosenfeld RG (2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells.". J. Clin. Endocrinol. Metab. 86 (9): 4504–11. PMID 11549700.
Wilson HM, Birnbaum RS, Poot M, et al. (2002). "Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism.". Cell Growth Differ. 13 (5): 205–13. PMID 12065244.
Usui T, Murai T, Tanaka T, et al. (2003). "Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells.". Int. Immunol. 14 (11): 1273–82. PMID 12407018.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Plymate SR, Haugk KH, Sprenger CC, et al. (2003). "Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1.". Oncogene 22 (7): 1024–34. doi:10.1038/sj.onc.1206210. PMID 12592389.
Domínguez F, Avila S, Cervero A, et al. (2003). "A combined approach for gene discovery identifies insulin-like growth factor-binding protein-related protein 1 as a new gene implicated in human endometrial receptivity.". J. Clin. Endocrinol. Metab. 88 (4): 1849–57. PMID 12679483.
López-Bermejo A, Khosravi J, Corless CL, et al. (2003). "Generation of anti-insulin-like growth factor-binding protein-related protein 1 (IGFBP-rP1/MAC25) monoclonal antibodies and immunoassay: quantification of IGFBP-rP1 in human serum and distribution in human fluids and tissues.". J. Clin. Endocrinol. Metab. 88 (7): 3401–8. PMID 12843194.
Nagakubo D, Murai T, Tanaka T, et al. (2003). "A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines.". J. Immunol. 171 (2): 553–61. PMID 12847218.