IGFBP5

From Wikipedia, the free encyclopedia


Insulin-like growth factor binding protein 5
PDB rendering based on 1boe.
Available structures: 1boe, 1h59
Identifiers
Symbol(s) IGFBP5; IBP5
External IDs OMIM: 146734 MGI: 96440 HomoloGene: 56489
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3488 16011
Ensembl ENSG00000115461 ENSMUSG00000026185
Uniprot P24593 Q3TT49
Refseq NM_000599 (mRNA)
NP_000590 (protein)		 NM_010518 (mRNA)
NP_034648 (protein)
Location Chr 2: 217.25 - 217.27 Mb Chr 1: 72.79 - 72.81 Mb
Pubmed search [1] [2]

Insulin-like growth factor binding protein 5, also known as IGFBP5, is a human gene.


[edit] Further reading

  • Mohan S, Farley JR, Baylink DJ (1996). "Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging.". Prog. Growth Factor Res. 6 (2-4): 465–73. PMID 8817691. 
  • Schneider MR, Wolf E, Hoeflich A, Lahm H (2002). "IGF-binding protein-5: flexible player in the IGF system and effector on its own.". J. Endocrinol. 172 (3): 423–40. PMID 11874691. 
  • Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824–54. PMID 12466191. 
  • Shimasaki S, Shimonaka M, Zhang HP, Ling N (1991). "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.". J. Biol. Chem. 266 (16): 10646–53. PMID 1709938. 
  • Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene.". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. PMID 1710112. 
  • Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.". Biochem. Biophys. Res. Commun. 176 (1): 213–8. PMID 1850257. 
  • Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein.". Biochem. Biophys. Res. Commun. 176 (1): 219–25. PMID 1850258. 
  • Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland.". Mol. Cell. Endocrinol. 97 (1-2): 71–9. PMID 7511544. 
  • Allander SV, Larsson C, Ehrenborg E, et al. (1994). "Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.". J. Biol. Chem. 269 (14): 10891–8. PMID 7511611. 
  • Kou K, James PL, Clemmons DR, et al. (1994). "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11.". Genomics 21 (3): 653–5. doi:10.1006/geno.1994.1329. PMID 7525452. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Nam TJ, Busby W, Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I.". Endocrinology 138 (7): 2972–8. PMID 9202242. 
  • Twigg SM, Baxter RC (1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.". J. Biol. Chem. 273 (11): 6074–9. PMID 9497324. 
  • Zheng B, Clarke JB, Busby WH, et al. (1998). "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin.". Endocrinology 139 (4): 1708–14. PMID 9528953. 
  • Twigg SM, Kiefer MC, Zapf J, Baxter RC (1998). "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain.". J. Biol. Chem. 273 (44): 28791–8. PMID 9786878. 
  • Kalus W, Zweckstetter M, Renner C, et al. (1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.". EMBO J. 17 (22): 6558–72. doi:10.1093/emboj/17.22.6558. PMID 9822601. 
  • Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.". FEBS Lett. 441 (2): 281–6. PMID 9883900. 
  • Kecha O, Martens H, Franchimont N, et al. (1999). "Characterization of the insulin-like growth factor axis in the human thymus.". J. Neuroendocrinol. 11 (6): 435–40. PMID 10336724. 
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