IGFBP3

From Wikipedia, the free encyclopedia

Insulin-like growth factor binding protein 3

Identifiers

IGFBP3; BP-53; IBP3

External IDs

Gene ontology
Molecular Function:	• insulin-like growth factor binding • protein tyrosine phosphatase activator activity • metal ion binding
Cellular Component:	• extracellular region
Biological Process:	• regulation of cell growth • negative regulation of signal transduction • positive regulation of apoptosis • positive regulation of myoblast differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000598 (mRNA)
NP_000589 (protein)

XM_001001532 (mRNA)
XP_001001532 (protein)

Location

Chr 7: 45.92 - 45.93 Mb

Chr 11: 7.11 - 7.11 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor binding protein 3, also known as IGFBP3, is a human gene.

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ Entrez Gene: IGFBP3 insulin-like growth factor binding protein 3.

[edit] Further reading

Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. PMID 9408744.
Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions.". Horm. Res. 51 (2): 53–67. PMID 10352394.
Schedlich LJ, Graham LD (2002). "Role of insulin-like growth factor binding protein-3 in breast cancer cell growth.". Microsc. Res. Tech. 59 (1): 12–22. doi:10.1002/jemt.10173. PMID 12242693.
Adham IM, Agoulnik AI (2005). "Insulin-like 3 signalling in testicular descent.". Int. J. Androl. 27 (5): 257–65. doi:10.1111/j.1365-2605.2004.00481.x. PMID 15379965.