IGFBP1

From Wikipedia, the free encyclopedia

Insulin-like growth factor binding protein 1

PDB rendering based on 1zt3.

Available structures: 1zt3, 1zt5, 2dsq

Identifiers

Symbol(s)

IGFBP1; IBP1; AFBP; IGF-BP25; PP12; hIGFBP-1

External IDs

OMIM: 146730 MGI: 96436 HomoloGene: 498

Gene ontology
Molecular Function:	• insulin-like growth factor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• regulation of cell growth • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000596 (mRNA)
NP_000587 (protein)

NM_008341 (mRNA)
NP_032367 (protein)

Location

Chr 7: 45.89 - 45.9 Mb

Chr 11: 7.1 - 7.1 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor binding protein 1, also known as IGFBP1, is a human gene.^[1]

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1.

[edit] Further reading

Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801-31. PMID 9408744.
Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions.". Horm. Res. 51 (2): 53-67. PMID 10352394.
Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824-54. PMID 12466191.
Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish.". Int. Rev. Cytol. 243: 215-85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461.
Ehrenborg E, Larsson C, Stern I, et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.". Genomics 12 (3): 497-502. PMID 1373120.
Ekstrand J, Ehrenborg E, Stern I, et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12.". Genomics 6 (3): 413-8. PMID 1691735.
Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1.". J. Biol. Chem. 265 (34): 21185-93. PMID 1701175.
Brinkman A, Kortleve DJ, Schuller AG, et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability.". FEBS Lett. 291 (2): 264-8. PMID 1718783.
Brewer MT, Stetler GL, Squires CH, et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein.". Biochem. Biophys. Res. Commun. 152 (3): 1289-97. PMID 2454104.
Julkunen M, Koistinen R, Aalto-Setälä K, et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.". FEBS Lett. 236 (2): 295-302. PMID 2457513.
Lee YL, Hintz RL, James PM, et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors.". Mol. Endocrinol. 2 (5): 404-11. PMID 2458522.
Brinkman A, Groffen C, Kortleve DJ, et al. (1989). "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1).". EMBO J. 7 (8): 2417-23. PMID 2461294.
Luthman H, Söderling-Barros J, Persson B, et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning.". Eur. J. Biochem. 180 (2): 259-65. PMID 2466665.
Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein.". Mol. Endocrinol. 3 (5): 846-51. PMID 2474129.
Alitalo T, Kontula K, Koistinen R, et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism.". Hum. Genet. 83 (4): 335-8. PMID 2478445.
Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1.". Biochem. Biophys. Res. Commun. 157 (3): 898-907. PMID 2849945.
Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions.". J. Biol. Chem. 263 (28): 14203-10. PMID 2971653.
Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin.". Nucleic Acids Res. 16 (17): 8711. PMID 3419931.
Jones JI, Gockerman A, Busby WH, et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553-7. PMID 7504269.
Jones JI, Busby WH, Wright G, et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101.". J. Biol. Chem. 268 (2): 1125-31. PMID 7678248.