IGFALS

From Wikipedia, the free encyclopedia

Insulin-like growth factor binding protein, acid labile subunit

Identifiers

External IDs

OMIM: 601489 MGI: 107973 HomoloGene: 37987

Gene ontology
Molecular Function:	• protein binding • insulin-like growth factor binding
Cellular Component:	• extracellular region • extracellular space • soluble fraction
Biological Process:	• cell adhesion • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004970 (mRNA)
NP_004961 (protein)

NM_008340 (mRNA)
NP_032366 (protein)

Location

Chr 16: 1.78 - 1.78 Mb

Chr 17: 24.61 - 24.61 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a human gene.^[1]

[edit] References

^ Entrez Gene: IGFALS insulin-like growth factor binding protein, acid labile subunit.

[edit] Further reading

Domené HM, Bengolea SV, Jasper HG, Boisclair YR (2005). "Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse.". J. Endocrinol. Invest. 28 (5 Suppl): 43–6. PMID 16114275.
Leong SR, Baxter RC, Camerato T, et al. (1992). "Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex.". Mol. Endocrinol. 6 (6): 870–6. PMID 1379671.
Dai J, Baxter RC (1992). "Molecular cloning of the acid-labile subunit of the rat insulin-like growth factor binding protein complex.". Biochem. Biophys. Res. Commun. 188 (1): 304–9. PMID 1384485.
Baxter RC, Martin JL, Beniac VA (1989). "High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum.". J. Biol. Chem. 264 (20): 11843–8. PMID 2473065.
Firth SM, Ganeshprasad U, Baxter RC (1998). "Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3.". J. Biol. Chem. 273 (5): 2631–8. PMID 9446566.
Twigg SM, Baxter RC (1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.". J. Biol. Chem. 273 (11): 6074–9. PMID 9497324.
Twigg SM, Kiefer MC, Zapf J, Baxter RC (1998). "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain.". J. Biol. Chem. 273 (44): 28791–8. PMID 9786878.
Suwanichkul A, Boisclair YR, Olney RC, et al. (2000). "Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes.". Endocrinology 141 (2): 833–8. PMID 10650966.
Ueki I, Ooi GT, Tremblay ML, et al. (2000). "Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system.". Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6868–73. doi:10.1073/pnas.120172697. PMID 10823924.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Sneppen SB, Lange M, Pedersen LM, et al. (2002). "Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly.". Growth Horm. IGF Res. 11 (6): 384–91. doi:10.1054/ghir.2001.0254. PMID 11914026.
Cisternino M, Draghi M, Lauriola S, et al. (2002). "The acid-labile subunit of human ternary insulin-like growth factor-binding protein complex in girls with central precocious puberty before and during gonadotropin-releasing hormone analog therapy.". J. Clin. Endocrinol. Metab. 87 (10): 4629–33. PMID 12364447.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Domené HM, Bengolea SV, Martínez AS, et al. (2004). "Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene.". N. Engl. J. Med. 350 (6): 570–7. doi:10.1056/NEJMoa013100. PMID 14762184.
Payet LD, Firth SM, Baxter RC (2004). "The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers.". J. Clin. Endocrinol. Metab. 89 (5): 2382–9. PMID 15126567.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Deming SL, Ren Z, Wen W, et al. (2007). "Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study.". Breast Cancer Res. Treat. 104 (3): 309–19. doi:10.1007/s10549-006-9420-8. PMID 17063263.