IGF2BP2

From Wikipedia, the free encyclopedia

Insulin-like growth factor 2 mRNA binding protein 2

PDB rendering based on 2cqh.

Available structures: 2cqh

Identifiers

Symbol(s)

IGF2BP2; p62; IMP-2; IMP2; VICKZ2

External IDs

OMIM: 608289 MGI: 1890358 HomoloGene: 4774

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• translational attenuation • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001007225 (mRNA)
NP_001007226 (protein)

NM_183029 (mRNA)
NP_898850 (protein)

Location

Chr 3: 186.84 - 187.03 Mb

Chr 16: 21.97 - 22.08 Mb

Pubmed search

[1]

[2]

Insulin-like growth factor 2 mRNA binding protein 2, also known as IGF2BP2, is a human gene.^[1]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2.

[edit] Further reading

Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.". Biol. Cell 97 (1): 87-96. doi:10.1042/BC20040151. PMID 15601260.
Nielsen J, Christiansen J, Lykke-Andersen J, et al. (1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.". Mol. Cell. Biol. 19 (2): 1262-70. PMID 9891060.
Zhang JY, Chan EK, Peng XX, Tan EM (1999). "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma.". J. Exp. Med. 189 (7): 1101-10. PMID 10190901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).". Biol. Chem. 384 (1): 25-37. PMID 12674497.
Brants JR, Ayoubi TA, Chada K, et al. (2004). "Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2.". FEBS Lett. 569 (1-3): 277-83. doi:10.1016/j.febslet.2004.05.075. PMID 15225648.
Ping S, Wang S, Zhang J, Peng X (2005). "Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells.". Int. J. Biochem. Cell Biol. 37 (3): 616-27. doi:10.1016/j.biocel.2004.08.007. PMID 15618018.
Hammer NA, Hansen TO, Byskov AG, et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.". Reproduction 130 (2): 203-12. doi:10.1530/rep.1.00664. PMID 16049158.
Natkunam Y, Vainer G, Chen J, et al. (2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms.". Haematologica 92 (2): 176-83. PMID 17296566.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Cleynen I, Brants JR, Peeters K, et al. (2007). "HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB.". Mol. Cancer Res. 5 (4): 363-72. doi:10.1158/1541-7786.MCR-06-0331. PMID 17426251.