IGBP1

From Wikipedia, the free encyclopedia

Immunoglobulin (CD79A) binding protein 1

Identifiers

External IDs

OMIM: 300139 MGI: 1346500 HomoloGene: 44067

Gene ontology
Molecular Function:	• protein phosphatase type 2A regulator activity
Cellular Component:	• cytoplasm
Biological Process:	• response to biotic stimulus • regulation of signal transduction • B cell activation

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001551 (mRNA)
NP_001542 (protein)

NM_008784 (mRNA)
NP_032810 (protein)

Location

n/a

Chr X: 96.7 - 96.72 Mb

Pubmed search

[1]

[2]

Immunoglobulin (CD79A) binding protein 1, also known as IGBP1, is a human gene.^[1]

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.^[1]

[edit] References

^ ^a ^b Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1.

[edit] Further reading

Onda M, Inui S, Maeda K, et al. (1998). "Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway.". Genomics 46 (3): 373–8. PMID 9441740.
Chen J, Peterson RT, Schreiber SL (1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6.". Biochem. Biophys. Res. Commun. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
Chung H, Nairn AC, Murata K, Brautigan DL (1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.". Biochemistry 38 (32): 10371–6. doi:10.1021/bi990902g. PMID 10441131.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. PMID 10508479.
Liu J, Prickett TD, Elliott E, et al. (2001). "Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.". Proc. Natl. Acad. Sci. U.S.A. 98 (12): 6650–5. doi:10.1073/pnas.111154698. PMID 11371618.
Short KM, Hopwood B, Yi Z, Cox TC (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.". BMC Cell Biol. 3: 1. PMID 11806752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Graham JM, Wheeler P, Tackels-Horne D, et al. (2004). "A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13.". Am. J. Med. Genet. A 123 (1): 37–44. doi:10.1002/ajmg.a.20504. PMID 14556245.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Smetana JH, Oliveira CL, Jablonka W, et al. (2006). "Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42.". Biochim. Biophys. Acta 1764 (4): 724–34. doi:10.1016/j.bbapap.2006.01.018. PMID 16517231.