IFT88

From Wikipedia, the free encyclopedia

Intraflagellar transport 88 homolog (Chlamydomonas)

Identifiers

IFT88; D13S1056E; MGC26259; RP11-172H24.2; TG737; TTC10; hTg737

External IDs

OMIM: 600595 MGI: 98715 HomoloGene: 4761

Gene ontology
Molecular Function:	• structural constituent of ribosome • binding • protein binding
Cellular Component:	• intracellular • ribosome • flagellum
Biological Process:	• translation • excretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006531 (mRNA)
NP_006522 (protein)

NM_009376 (mRNA)
NP_033402 (protein)

Location

Chr 13: 20.04 - 20.16 Mb

Chr 14: 56.38 - 56.47 Mb

Pubmed search

[1]

[2]

Intraflagellar transport 88 homolog (Chlamydomonas), also known as IFT88, is a human gene.^[1]

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: IFT88 intraflagellar transport 88 homolog (Chlamydomonas).

[edit] Further reading

Murcia NS, Sweeney WE, Avner ED (1999). "New insights into the molecular pathophysiology of polycystic kidney disease.". Kidney Int. 55 (4): 1187-97. doi:10.1046/j.1523-1755.1999.00370.x. PMID 10200981.
Schrick JJ, Onuchic LF, Reeders ST, et al. (1995). "Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene.". Hum. Mol. Genet. 4 (4): 559-67. PMID 7633404.
Moyer JH, Lee-Tischler MJ, Kwon HY, et al. (1994). "Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.". Science 264 (5163): 1329-33. PMID 8191288.
Onuchic LF, Schrick JJ, Ma J, et al. (1996). "Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease.". Mamm. Genome 6 (11): 805-8. PMID 8597639.
Isfort RJ, Cody DB, Doersen CJ, et al. (1997). "The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene.". Oncogene 15 (15): 1797-803. doi:10.1038/sj.onc.1201535. PMID 9362446.
Bonura C, Paterlini-Brechot P, Brechot C (1999). "Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas.". Hepatology 30 (3): 677-81. doi:10.1002/hep.510300325. PMID 10462374.
Taulman PD, Haycraft CJ, Balkovetz DF, Yoder BK (2001). "Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia.". Mol. Biol. Cell 12 (3): 589-99. PMID 11251073.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440-5. doi:10.1038/88107. PMID 11329013.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Khanna H, Hurd TW, Lillo C, et al. (2005). "RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins.". J. Biol. Chem. 280 (39): 33580-7. doi:10.1074/jbc.M505827200. PMID 16043481.
Robert A, Margall-Ducos G, Guidotti JE, et al. (2007). "The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells.". J. Cell. Sci. 120 (Pt 4): 628-37. doi:10.1242/jcs.03366. PMID 17264151.