IFNB1

From Wikipedia, the free encyclopedia

Interferon, beta 1, fibroblast

PDB rendering based on 1au1.

Available structures: 1au1

Identifiers

Symbol(s)

IFNB1; IFB; IFF; IFNB; MGC96956

External IDs

OMIM: 147640 MGI: 107657 HomoloGene: 1640

Gene ontology
Molecular Function:	• interferon-alpha/beta receptor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• induction of apoptosis • caspase activation • cell surface receptor linked signal transduction • negative regulation of cell proliferation • response to virus • natural killer cell activation • B cell proliferation • defense response to bacterium • positive regulation of innate immune response • regulation of MHC class I biosynthetic process • negative regulation of virion penetration into host

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002176 (mRNA)
NP_002167 (protein)

NM_010510 (mRNA)
NP_034640 (protein)

Location

Chr 9: 21.07 - 21.07 Mb

Chr 4: 87.99 - 87.99 Mb

Pubmed search

[1]

[2]

Interferon, beta 1, fibroblast, also known as IFNB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: IFNB1 interferon, beta 1, fibroblast.

[edit] Further reading

Biron CA, Nguyen KB, Pien GC (2002). "Innate immune responses to LCMV infections: natural killer cells and cytokines.". Curr. Top. Microbiol. Immunol. 263: 7-27. PMID 11987821.
Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1-2): 99-115. PMID 15481145.
Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega.". Growth Factors 22 (4): 243-51. doi:10.1080/08977190400000833. PMID 15621727.
Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093-101. PMID 16375755.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69-77. PMID 1708818.
Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor.". J. Biol. Chem. 266 (30): 19875-7. PMID 1834641.
May LT, Sehgal PB (1985). "On the relationship between human interferon alpha 1 and beta 1 genes.". J. Interferon Res. 5 (3): 521-6. PMID 2414376.
Francois DT, Katona IM, June CH, et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens.". Clin. Immunol. Immunopathol. 48 (3): 297-306. PMID 3135963.
Conradt HS, Egge H, Peter-Katalinic J, et al. (1987). "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line.". J. Biol. Chem. 262 (30): 14600-5. PMID 3667593.
Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation.". J. Interferon Res. 5 (1): 215-21. PMID 3872918.
Derynck R, Content J, DeClercq E, et al. (1980). "Isolation and structure of a human fibroblast interferon gene.". Nature 285 (5766): 542-7. PMID 6157094.
Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA.". Gene 10 (1): 11-5. PMID 6157601.
Houghton M, Easton MA, Stewart AG, et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase.". Nucleic Acids Res. 8 (13): 2885-94. PMID 6159580.
Goeddel DV, Shepard HM, Yelverton E, et al. (1981). "Synthesis of human fibroblast interferon by E. coli.". Nucleic Acids Res. 8 (18): 4057-74. PMID 6159584.
Houghton M, Stewart AG, Doel SM, et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers.". Nucleic Acids Res. 8 (9): 1913-31. PMID 6159597.
Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon.". Nature 289 (5798): 606-7. PMID 6162107.
Lawn RM, Adelman J, Franke AE, et al. (1981). "Human fibroblast interferon gene lacks introns.". Nucleic Acids Res. 9 (5): 1045-52. PMID 6164984.
Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity.". Nature 294 (5841): 563-5. PMID 6171735.
Content J, De Wit L, Pierard D, et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta.". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768-72. PMID 6178110.
Fiers W, Remaut E, Devos R, et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 299 (1094): 29-38. PMID 6183692.