IFNA4

From Wikipedia, the free encyclopedia

Interferon, alpha 4

Identifiers

IFNA4; INFA4; MGC142200

External IDs

OMIM: 147564 MGI: 107668 HomoloGene: 68536

Gene ontology
Molecular Function:	• interferon-alpha/beta receptor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• defense response • cell-cell signaling • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021068 (mRNA)
NP_066546 (protein)

NM_010502 (mRNA)
NP_034632 (protein)

Location

Chr 9: 21.18 - 21.18 Mb

Chr 4: 88.32 - 88.32 Mb

Pubmed search

[1]

[2]

Interferon, alpha 4, also known as IFNA4, is a human gene.^[1]

[edit] References

^ Entrez Gene: IFNA4 interferon, alpha 4.

[edit] Further reading

Olopade OI, Bohlander SK, Pomykala H, et al. (1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.". Genomics 14 (2): 437-43. PMID 1385305.
Mizoguchi J, Pitha PM, Raj NB (1985). "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules.". DNA 4 (3): 221-32. PMID 3891272.
Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes.". J. Mol. Biol. 185 (2): 227-60. PMID 4057246.
Linnane AW, Beilharz MW, McMullen GL, et al. (1984). "Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides.". Biochem. Int. 8 (5): 725-32. PMID 6089830.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.". Mol. Cell. Biol. 16 (7): 3934-44. PMID 8668211.
Hussain M, Gill DS, Liao MJ (1997). "Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population.". J. Interferon Cytokine Res. 17 (9): 559-66. PMID 9335434.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.". Biochem. J. 329 ( Pt 2): 295-302. PMID 9425112.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yokota S, Yokosawa N, Okabayashi T, et al. (2004). "Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.". J. Virol. 78 (12): 6282-6. doi:10.1128/JVI.78.12.6282-6286.2004. PMID 15163721.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.