IFNA2

From Wikipedia, the free encyclopedia

Interferon, alpha 2

PDB rendering based on 1itf.

Available structures: 1itf, 1rh2, 2hym

Identifiers

Symbol(s)

IFNA2; IFNA; INFA2; MGC125764; MGC125765

External IDs

OMIM: 147562 HomoloGene: 86655

Gene ontology
Molecular Function:	• interferon-alpha/beta receptor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• induction of apoptosis • inflammatory response • cell surface receptor linked signal transduction • cell-cell signaling • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_000605 (mRNA)
NP_000596 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 9: 21.37 - 21.38 Mb

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Pubmed search

[1]

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Interferon, alpha 2, also known as IFNA2, is a human gene.^[1]

[edit] References

^ Entrez Gene: IFNA2 interferon, alpha 2.

[edit] Further reading

Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1-2): 99–115. PMID 15481145.
Capobianchi MR, Ankel H, Ameglio F, et al. (1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer.". AIDS Res. Hum. Retroviruses 8 (5): 575–9. PMID 1381203.
Olopade OI, Bohlander SK, Pomykala H, et al. (1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.". Genomics 14 (2): 437–43. PMID 1385305.
Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor.". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.
Tyring SK, Cauda R, Tumbarello M, et al. (1991). "Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2.". Viral Immunol. 4 (1): 33–42. PMID 1905933.
Adolf GR, Kalsner I, Ahorn H, et al. (1991). "Natural human interferon-alpha 2 is O-glycosylated.". Biochem. J. 276 ( Pt 2): 511–8. PMID 2049076.
Stine KC, Bolognesi D, Weinhold KJ (1989). "Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.". Journal of biological response modifiers 8 (5): 501–10. PMID 2552026.
Oliver G, Balbás P, Valle F, et al. (1986). "[Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli]". Rev. Latinoam. Microbiol. 27 (2): 141–50. PMID 3906813.
Streuli M, Nagata S, Weissmann C (1980). "At least three human type alpha interferons: structure of alpha 2.". Science 209 (4463): 1343–7. PMID 6158094.
Allen G, Fantes KH (1981). "A family of structural genes for human lymphoblastoid (leukocyte-type) interferon.". Nature 287 (5781): 408–11. PMID 6159537.
Goeddel DV, Yelverton E, Ullrich A, et al. (1981). "Human leukocyte interferon produced by E. coli is biologically active.". Nature 287 (5781): 411–6. PMID 6159538.
Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon.". Nature 289 (5798): 606–7. PMID 6162107.
Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs.". Nature 290 (5801): 20–6. PMID 6163083.
Maeda S, McCandliss R, Gross M, et al. (1981). "Construction and identification of bacterial plasmids containing nucleotide sequence for human leukocyte interferon.". Proc. Natl. Acad. Sci. U.S.A. 77 (12): 7010–3. PMID 6164056.
Lawn RM, Gross M, Houck CM, et al. (1982). "DNA sequence of a major human leukocyte interferon gene.". Proc. Natl. Acad. Sci. U.S.A. 78 (9): 5435–9. PMID 6170983.
Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.". Nucleic Acids Res. 11 (16): 5661–9. PMID 6310510.
Ameglio F, Capobianchi MR, Castilletti C, et al. (1994). "Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines.". Clin. Exp. Immunol. 95 (3): 455–8. PMID 7511078.
Ankel H, Capobianchi MR, Castilletti C, Dianzani F (1994). "Interferon induction by HIV glycoprotein 120: role of the V3 loop.". Virology 205 (1): 34–43. doi:10.1006/viro.1994.1617. PMID 7526537.
Nair MP, Chadha KC, Stadler I, et al. (1995). "Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates.". Clin. Diagn. Lab. Immunol. 2 (4): 434–8. PMID 7583919.
Lee N, Ni D, Brissette R, et al. (1995). "Interferon-alpha 2 variants in the human genome.". J. Interferon Cytokine Res. 15 (4): 341–9. PMID 7627809.