IFNA1

From Wikipedia, the free encyclopedia

Interferon, alpha 1

Identifiers

IFNA1; IFL; IFN; IFN-ALPHA; IFNA13; IFNA@; MGC138207; MGC138505; MGC138507

External IDs

Gene ontology
Molecular Function:	• hematopoietin/interferon-class (D200-domain) cytokine receptor binding • interferon-alpha/beta receptor binding
Cellular Component:	• extracellular region • extracellular space
Biological Process:	• defense response • response to virus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_024013 (mRNA)
NP_076918 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 9: 21.43 - 21.43 Mb

n/a

Pubmed search

[1]

n/a

Interferon, alpha 1, also known as IFNA1, is a human gene.^[1]

Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: IFNA1 interferon, alpha 1.

[edit] Further reading

Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1-2): 99-115. PMID 15481145.
Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega.". Growth Factors 22 (4): 243-51. doi:10.1080/08977190400000833. PMID 15621727.
Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093-101. PMID 16375755.
Capobianchi MR, Ankel H, Ameglio F, et al. (1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer.". AIDS Res. Hum. Retroviruses 8 (5): 575-9. PMID 1381203.
Olopade OI, Bohlander SK, Pomykala H, et al. (1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.". Genomics 14 (2): 437-43. PMID 1385305.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69-77. PMID 1708818.
Delcayre AX, Salas F, Mathur S, et al. (1991). "Epstein Barr virus/complement C3d receptor is an interferon alpha receptor.". EMBO J. 10 (4): 919-26. PMID 1849076.
Tyring SK, Cauda R, Tumbarello M, et al. (1991). "Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2.". Viral Immunol. 4 (1): 33-42. PMID 1905933.
Göttlinger HG, Dorfman T, Sodroski JG, Haseltine WA (1991). "Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3195-9. PMID 2014240.
Stine KC, Bolognesi D, Weinhold KJ (1989). "Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.". Journal of biological response modifiers 8 (5): 501-10. PMID 2552026.
Capon DJ, Shepard HM, Goeddel DV (1985). "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.". Mol. Cell. Biol. 5 (4): 768-79. PMID 2985969.
Delfraissy JF, Wallon C, Galanaud P (1988). "Interferon-alpha can synergize with interleukin 2 for human in vitro antibody response.". Eur. J. Immunol. 18 (9): 1379-84. PMID 3262520.
Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes.". J. Mol. Biol. 185 (2): 227-60. PMID 4057246.
Taniguchi T, Mantei N, Schwarzstein M, et al. (1980). "Human leukocyte and fibroblast interferons are structurally related.". Nature 285 (5766): 547-9. PMID 6157095.
Mantei N, Schwarzstein M, Streuli M, et al. (1980). "The nucleotide sequence of a cloned human leukocyte interferon cDNA.". Gene 10 (1): 1-10. PMID 6157600.
Nagata S, Mantei N, Weissmann C (1981). "The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.". Nature 287 (5781): 401-8. PMID 6159536.
Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs.". Nature 290 (5801): 20-6. PMID 6163083.
Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.". Nucleic Acids Res. 11 (16): 5661-9. PMID 6310510.
Todokoro K, Kioussis D, Weissmann C (1984). "Two non-allelic human interferon alpha genes with identical coding regions.". EMBO J. 3 (8): 1809-12. PMID 6479148.
Ameglio F, Capobianchi MR, Castilletti C, et al. (1994). "Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines.". Clin. Exp. Immunol. 95 (3): 455-8. PMID 7511078.