Ifenprodil
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| Ifenprodil | |
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| IUPAC name | 4-[2-[4-(cyclohexylmethyl)- 1-piperidinyl]-1-hydroxypropyl]phenol |
| Identifiers | |
| CAS number | [245-491-4] |
| PubChem | |
| SMILES | CC(C(C1=CC=C(C=C1)O)O) N2CCC(CC2)CC3=CC=CC=C3 |
| Properties | |
| Molecular formula | C21H27NO2 |
| Molar mass | 325.445 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Ifenprodil is a selective inhibitor of the NMDA receptor.[1]
[edit] References
- ^ Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758–65. PMID 2555674.
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NMDA receptors are multimeric ionotropic glutamate receptors composed of likely four subunits. NR1 is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.
