Idoxuridine

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Idoxuridine
Systematic (IUPAC) name
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]- 5-iodo-pyrimidine-2,4-dione
Identifiers
CAS number	54-42-2
ATC code	D06BB01 J05AB02, S01AD01
PubChem	5905
DrugBank	APRD00504
Chemical data
Formula	C9H11IN2O5
Mol. mass	354.099 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	intravenously

Idoxuridine is an anti-herpesvirus antiviral drug.

It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing.

[edit] External links

• Seth A, Misra A, Umrigar D (2004). "Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.". Pharm Dev Technol 9 (3): 277–89. doi:10.1081/PDT-200031432. PMID 15458233. 
• Otto S. "Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine).". J Intraven Nurs 21 (6): 335–7. PMID 10392098. 
• Fauth E, Zankl H (1999). "Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting.". Mutat Res 440 (2): 147–56. PMID 10209337. 

v • d • e Antibiotics and chemotherapeutics for dermatological use (D06) Antibiotics: tetracycline and derivatives Demeclocycline - Chlortetracycline - Oxytetracycline - Tetracycline Antibiotics: other Fusidic acid - Chloramphenicol - Neomycin - Bacitracin - Gentamicin - Tyrothricin - Mupirocin - Nadifloxacin - Virginiamycin - Rifaximin - Amikacin Chemotherapeutics: sulfonamides Silver sulfadiazine - Sulfathiazole - Mafenide - Sulfamethizole - Sulfanilamide - Sulfamerazine Chemotherapeutics: antivirals Idoxuridine - Tromantadine - Aciclovir - Podophyllotoxin - Inosine - Penciclovir - Lysozyme - Ibacitabine - Edoxudine - Imiquimod - Docosanol Chemotherapeutics: other Metronidazole

v • d • e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB) Anti-herpesvirus (DNA, I) purine analogue (guanine) (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • Vidarabine pyrimidine analogue (uridine) (Idoxuridine, Trifluridine) • Cidofovir Docosanol • Fomivirsen • Foscarnet • Tromantadine HPV/MC (DNA, I) Imiquimod • Podophyllotoxin Hepatitis B (DNA, VII) Adefovir • Clevudine • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir† Hepatitis C (RNA, IV) Pegylated interferon alpha • Ribavirin • Taribavirin† • Boceprevir† Picornavirus (RNA, IV) Pleconaril† Anti-influenza agents (RNA, V) Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir†) HIV (Reverse, VI) See HIV pharm Other antiviral agents general (Inosine, Interferon) †Undergoing clinical trials, not FDA approved.