ID4 (gene)

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Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Identifiers
Symbol(s) ID4;
External IDs OMIM: 600581 MGI: 99414 HomoloGene: 1186
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3400 15904
Ensembl ENSG00000172201 ENSMUSG00000021379
Uniprot P47928 Q544D2
Refseq NM_001546 (mRNA)
NP_001537 (protein)		 XM_993031 (mRNA)
XP_998125 (protein)
Location Chr 6: 19.95 - 19.95 Mb Chr 13: 48.27 - 48.28 Mb
Pubmed search [1] [2]

Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein, also known as ID4, is a human gene.[1]

Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein.

[edit] Further reading

  • Pagliuca A, Bartoli PC, Saccone S, et al. (1995). "Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22.". Genomics 27 (1): 200-3. doi:10.1006/geno.1995.1026. PMID 7665172. 
  • Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein.". Nucleic Acids Res. 24 (14): 2813-20. PMID 8759016. 
  • Stewart HJ, Zoidl G, Rossner M, et al. (1998). "Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development.". J. Neurosci. Res. 50 (5): 684-701. PMID 9418957. 
  • Rigolet M, Rich T, Gross-Morand MS, et al. (1999). "cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene.". DNA Res. 5 (5): 309-13. PMID 9872455. 
  • Beger C, Pierce LN, Kruger M, et al. (2001). "Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach.". Proc. Natl. Acad. Sci. U.S.A. 98 (1): 130-5. doi:10.1073/pnas.98.1.130. PMID 11136250. 
  • Jögi A, Persson P, Grynfeld A, et al. (2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation.". J. Biol. Chem. 277 (11): 9118-26. doi:10.1074/jbc.M107713200. PMID 11756408. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bellido M, Aventín A, Lasa A, et al. (2004). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia.". Haematologica 88 (9): 994-1001. PMID 12969807. 
  • Chan AS, Tsui WY, Chen X, et al. (2003). "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma.". Oncogene 22 (44): 6946-53. doi:10.1038/sj.onc.1206799. PMID 14534543. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Shan L, Yu M, Qiu C, Snyderwine EG (2004). "Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas.". Am. J. Pathol. 163 (6): 2495-502. PMID 14633621. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Umetani N, Takeuchi H, Fujimoto A, et al. (2005). "Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis.". Clin. Cancer Res. 10 (22): 7475-83. doi:10.1158/1078-0432.CCR-04-0689. PMID 15569977. 
  • Yu L, Liu C, Vandeusen J, et al. (2005). "Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia.". Nat. Genet. 37 (3): 265-74. doi:10.1038/ng1521. PMID 15723065. 
  • Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA (2006). "Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer.". Mol. Cancer 4 (1): 16. doi:10.1186/1476-4598-4-16. PMID 15876350. 
  • Peddada S, Yasui DH, LaSalle JM (2006). "Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome.". Hum. Mol. Genet. 15 (12): 2003-14. doi:10.1093/hmg/ddl124. PMID 16682435. 
  • Hagiwara K, Nagai H, Li Y, et al. (2007). "Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma.". Journal of clinical and experimental hematopathology : JCEH 47 (1): 15-8. PMID 17510533. 
  • Noetzel E, Veeck J, Niederacher D, et al. (2008). "Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer.". BMC Cancer. R8 (154). doi:10.1186/1471-2407-8-154. PMID 18513385. 

[edit] External links


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD