ICMT

From Wikipedia, the free encyclopedia

Isoprenylcysteine carboxyl methyltransferase

Identifiers

ICMT; HSTE14; MGC39955; MST098; MSTP098; PCCMT; PCMT; PPMT

External IDs

OMIM: 605851 MGI: 1888594 HomoloGene: 5735

Gene ontology
Molecular Function:	• protein-S-isoprenylcysteine O-methyltransferase activity • methyltransferase activity • transferase activity
Cellular Component:	• membrane fraction • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• protein modification process • C-terminal protein amino acid methylation • protein targeting to membrane • protein localization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012405 (mRNA)
NP_036537 (protein)

NM_133788 (mRNA)
NP_598549 (protein)

Location

Chr 1: 6.2 - 6.22 Mb

Chr 4: 151.14 - 151.15 Mb

Pubmed search

[1]

[2]

Isoprenylcysteine carboxyl methyltransferase, also known as ICMT, is a human gene.^[1]

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase.

[edit] Further reading

Dai Q, Choy E, Chiu V, et al. (1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum.". J. Biol. Chem. 273 (24): 15030-4. PMID 9614111.
Choy E, Chiu VK, Silletti J, et al. (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi.". Cell 98 (1): 69-80. doi:10.1016/S0092-8674(00)80607-8. PMID 10412982.
Desrosiers RR, Nguyen QT, Béliveau R (1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme.". Biochem. Biophys. Res. Commun. 261 (3): 790-7. doi:10.1006/bbrc.1999.0936. PMID 10441503.
Lin X, Antalffy B, Kang D, et al. (2000). "Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.". Nat. Neurosci. 3 (2): 157-63. doi:10.1038/72101. PMID 10649571.
Van Dessel GA, De Busser HM, Lagrou AR (2002). "Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells.". Int. J. Biochem. Cell Biol. 34 (5): 477-86. PMID 11906819.
Ahmad M, Zhang Y, Zhang Y, et al. (2002). "Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells.". Arterioscler. Thromb. Vasc. Biol. 22 (5): 759-64. PMID 12006387.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kramer K, Harrington EO, Lu Q, et al. (2004). "Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis.". Mol. Biol. Cell 14 (3): 848-57. doi:10.1091/mbc.E02-07-0390. PMID 12631708.
Winter-Vann AM, Kamen BA, Bergo MO, et al. (2003). "Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6529-34. doi:10.1073/pnas.1135239100. PMID 12750467.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bergo MO, Gavino BJ, Hong C, et al. (2004). "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.". J. Clin. Invest. 113 (4): 539-50. doi:10.1172/JCI200418829. PMID 14966563.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lu Q, Harrington EO, Newton J, et al. (2007). "Inhibition of ICMT induces endothelial cell apoptosis through GRP94.". Am. J. Respir. Cell Mol. Biol. 37 (1): 20-30. doi:10.1165/rcmb.2006-0301SM. PMID 17347446.