ICAM3

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Intercellular adhesion molecule 3
PDB rendering based on 1t0p.
Available structures: 1t0p
Identifiers
Symbol(s) ICAM3; CD50; CDW50; ICAM-R
External IDs OMIM: 146631 HomoloGene: 88479
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3385 n/a
Ensembl ENSG00000076662 n/a
Uniprot P32942 n/a
Refseq NM_002162 (mRNA)
NP_002153 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 19: 10.31 - 10.31 Mb n/a
Pubmed search [1] n/a

Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a human gene.

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: ICAM3 intercellular adhesion molecule 3.

[edit] Further reading

  • Simmons DL (1995). "The role of ICAM expression in immunity and disease.". Cancer Surv. 24: 141–55. PMID 7553659. 
  • Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions.". Immunol. Res. 17 (3): 313–27. PMID 9638475. 
  • Fawcett J, Holness CL, Needham LA, et al. (1992). "Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.". Nature 360 (6403): 481–4. doi:10.1038/360481a0. PMID 1448173. 
  • Vazeux R, Hoffman PA, Tomita JK, et al. (1992). "Cloning and characterization of a new intercellular adhesion molecule ICAM-R.". Nature 360 (6403): 485–8. doi:10.1038/360485a0. PMID 1448174. 
  • Pino-Otín MR, Juan M, de la Fuente MA, et al. (1995). "CD50 (intercellular adhesion molecule-3) is expressed at higher levels on memory than on naive human T cells but induces a similar calcium mobilization on both subsets.". Tissue Antigens 46 (1): 32–44. PMID 7482494. 
  • Marazuela M, Postigo AA, Acevedo A, et al. (1994). "Adhesion molecules from the LFA-1/ICAM-1,3 and VLA-4/VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves' and Hashimoto's thyroid glands.". Eur. J. Immunol. 24 (10): 2483–90. PMID 7523142. 
  • Holness CL, Bates PA, Little AJ, et al. (1995). "Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1.". J. Biol. Chem. 270 (2): 877–84. PMID 7822326. 
  • Martin S, Rieckmann P, Melchers I, et al. (1995). "Circulating forms of ICAM-3 (cICAM-3). Elevated levels in autoimmune diseases and lack of association with cICAM-1.". J. Immunol. 154 (4): 1951–5. PMID 7836774. 
  • Bossy D, Mattei MG, Simmons DL (1995). "The human intercellular adhesion molecule 3 (ICAM3) gene is located in the 19p13.2-p13.3 region, close to the ICAM1 gene.". Genomics 23 (3): 712–3. doi:10.1006/geno.1994.1565. PMID 7851905. 
  • Skubitz KM, Ahmed K, Campbell KD, Skubitz AP (1995). "CD50 (ICAM-3) is phosphorylated on tyrosine and is associated with tyrosine kinase activity in human neutrophils.". J. Immunol. 154 (6): 2888–95. PMID 7876557. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Juan M, Vilella R, Mila J, et al. (1993). "CDw50 and ICAM-3: two names for the same molecule.". Eur. J. Immunol. 23 (7): 1508–12. PMID 8325327. 
  • de Fougerolles AR, Klickstein LB, Springer TA (1993). "Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.". J. Exp. Med. 177 (4): 1187–92. PMID 8459213. 
  • Hosaka S, Shah MR, Pope RM, Koch AE (1996). "Soluble forms of P-selectin and intercellular adhesion molecule-3 in synovial fluids.". Clin. Immunol. Immunopathol. 78 (3): 276–82. PMID 8605703. 
  • Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.". Immunity 3 (6): 683–90. PMID 8777714. 
  • Hayflick JS, Stine J, Fox R, et al. (1997). "Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues.". J. Biol. Chem. 272 (35): 22207–14. PMID 9268366. 
  • Serrador JM, Alonso-Lebrero JL, del Pozo MA, et al. (1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization.". J. Cell Biol. 138 (6): 1409–23. PMID 9298994. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60. PMID 9473377. 

[edit] External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350