ICAM-1
From Wikipedia, the free encyclopedia
- See also: Cell adhesion molecule
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Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
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| PDB rendering based on 1d3e. | ||||||||||||||
| Available structures: 1d3e, 1d3i, 1d3l, 1iam, 1ic1, 1mq8, 1p53, 1z7z | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | ICAM1; BB2; CD54; P3.58 | |||||||||||||
| External IDs | OMIM: 147840 MGI: 96392 HomoloGene: 168 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3383 | 15894 | ||||||||||||
| Ensembl | ENSG00000090339 | ENSMUSG00000037405 | ||||||||||||
| Uniprot | P05362 | Q3TB10 | ||||||||||||
| Refseq | NM_000201 (mRNA) NP_000192 (protein) |
NM_010493 (mRNA) NP_034623 (protein) |
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| Location | Chr 19: 10.24 - 10.26 Mb | Chr 9: 20.77 - 20.78 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes binds to endothelial cells via ICAM-1/LFA-1 and then transmigrates into tissuesEntrez PubMed 15811956.
ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.[1] [2] While ICAM-1 has not been shown to be directly correlated with cerebral vasospasm, a secondary insult which affects 70% of SAH patients, treatment with anti-ICAM-1 reduced the severity of vasospasm.
[edit] References
- ^ Polin RS, Bavbek M, Shaffrey ME, Billups K, Bogaev CA, Kassell NF, Lee KS: Detection of soluble E-selectin, ICAM-1, VCAM-1 and L-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage. Journal of Neurosurgery 89:559-567,1998.Entrez PubMed 9761049
- ^ Frijns CJM, Kappelle LJ: Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease. Stroke 33:2115-2122,2002. Entrez PubMed 12154274
[edit] Further reading
- Wahl SM, Greenwell-Wild T, Hale-Donze H, et al. (2000). "Permissive factors for HIV-1 infection of macrophages.". J. Leukoc. Biol. 68 (3): 303–10. PMID 10985244.
- Yonekawa K, Harlan JM (2005). "Targeting leukocyte integrins in human diseases.". J. Leukoc. Biol. 77 (2): 129–40. doi:. PMID 15548573.
- Chakravorty SJ, Craig A (2005). "The role of ICAM-1 in Plasmodium falciparum cytoadherence.". Eur. J. Cell Biol. 84 (1): 15–27. PMID 15724813.
- Lebedeva T, Dustin ML, Sykulev Y (2005). "ICAM-1 co-stimulates target cells to facilitate antigen presentation.". Curr. Opin. Immunol. 17 (3): 251–8. doi:. PMID 15886114.
- Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW (2005). "ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.". Blood. 106 (2): 584–92. doi:. PMID 15811956.
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[edit] External links
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