iC3b

From Wikipedia, the free encyclopedia

The introduction to this article provides insufficient context for those unfamiliar with the subject. Please help improve the article with a good introductory style.

This article does not cite any references or sources. (December 2007) Please help improve this article by adding citations to reliable sources. Unverifiable material may be challenged and removed.

iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b^[1] that still opsonizes microbes, but cannot associate with factor B. Thus preventing amplification of the of the complement cascade or activation through the alternative pathway.

[edit] References

v • d • e Proteins: complement system (C, L, A) Activators CLA: C3-convertase - C5-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin Enzymes C: C1Q/C1R/C1S - C4 (C4a) - C2 - CLA: C3 (C3a, C3b/iC3b) - C5 (C5a) - L: MASP1 - MASP2 - A: Complement factor B - Factor D Inhibitors CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

v • d • e Immune system / Immunology Systems Adaptive immune system vs. Innate immune system • Humoral immune system vs. Cellular immune system • Complement system (Anaphylatoxins) • Intrinsic immune system Antibodies and antigens Antibody (Monoclonal antibodies, Polyclonal antibodies, Autoantibody) • Allotype • Isotype • Idiotype • Antigen (Superantigen) • Polyclonal response Immune cells White blood cells (T cell, B cell, NK cell, Mast cell, Basophil, Eosinophil) • Phagocyte (Neutrophil, Macrophage, Dendritic cell) • Antigen-presenting cell • Reticuloendothelial system Immunity vs. tolerance Immunity • Autoimmunity • Allergy • Tolerance (Central) • Immunodeficiency Immunogenetics Somatic hypermutation • V(D)J recombination • Immunoglobulin class switching • MHC/HLA Substances Cytokines • Opsonin • Cytolysin Other Inflammation • Epitope (Hapten) • Cross-reactivity • Diagnostic immunology