Hypouricemia
From Wikipedia, the free encyclopedia
| Hypouricemia Classification and external resources |
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| Uric acid | |
| DiseasesDB | 21432 |
Hypouricemia is a condition where the level of uric acid is below a certain threshold (between 2 mg/dL and 4 mg/dL, according to different sources.) The upper end of the normal range is 530 micromol/L (6 mg/dL) for women and 619 micromol/L (7 mg/dL) for men. [1]
[edit] Associated conditions
Hypouricemia is associated with several conditions, including:
Half of the cases can be associated with drugs (allopurinol) and toxic agents. Uric acid clearance should also be performed, increase in clearance points to proximal tubular defects in the kidney, normal or reduced clearance points to a defect in xanthine oxidase.
It can also be associated with total parenteral nutrition. [3]
Vegetarian diet has been found to result in mean serum uric acid values as low as 239 micromol/L (2.7 mg/dL).[4] While a vegetarian diet is typically seen as beneficial with respect to conditions such as gout,[4] care should be taken to avoid hypouricemia and associated health conditions.
A specific condition, Dalmatian hypouricemia, is known to have a genetic component. [5]
In one study, hypouricemia was found in 4.8% of hospitalized women and 6.5% of hospitalized men. (The definition was less than 0.14 mmol l-1 for women and less than 0.20 mmol l-1 in men.) [6]
An association with URAT1 has been identified.[7][8]
[edit] See also
[edit] References
- ^ Chizyński K, Rózycka M (November 2005). "[Hyperuricemia]" (in Polish). Pol. Merkur. Lekarski 19 (113): 693–6. PMID 16498814.
- ^ Toncev G, Milicic B, Toncev S, Samardzic G (May 2002). "Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood-brain barrier dysfunction". Eur. J. Neurol. 9 (3): 221–6. PMID 11985629.
- ^ Koretz RL (November 1981). "Hypouricemia--a transient biochemical phenomenon of total parenteral nutrition". Am. J. Clin. Nutr. 34 (11): 2493–8. PMID 6795918.
- ^ a b Szeto YT, Kwok TC, Benzie IF (October 2004). "Effects of a long-term vegetarian diet on biomarkers of antioxidant status and cardiovascular disease risk". Nutrition 20 (10): 863–6. doi:. PMID 15474873.
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 220150
- ^ Crook M (December 1993). "Hypouricaemia in a hospital population". Scand. J. Clin. Lab. Invest. 53 (8): 883–5. PMID 8140400.
- ^ Ichida K, Hosoyamada M, Kamatani N, et al (May 2008). "Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese". Clin. Genet.. doi:. PMID 18492088.
- ^ Takahashi T, Tsuchida S, Oyamada T, et al (May 2005). "Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese". Pediatr. Nephrol. 20 (5): 576–8. doi:. PMID 15772829.
